Evidence map›Paper›PMID 29941603›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

miR-34a directly targets tRNA

Bo Wang, Dongping Li, Igor Kovalchuk, Ingrid J Apel, Arul M Chinnaiyan, Rafał K Wóycicki, Charles R Cantor, Olga Kovalchuk

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. A miR-34a-guided, tRNACell death discovery · 2022
    Article
  9. Downregulation ofWorld journal of gastroenterology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Suppression of circulatingOncology letters · 2021
    Article
  18. Article
  19. Role of tRNAs in Breast Cancer Regulation.Advances in experimental medicine and biology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Bo WangDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Dongping LiDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Igor KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Ingrid J ApelMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Arul M ChinnaiyanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109.
Rafał K WóycickiDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4.
Charles R CantorDepartment of Biomedical Engineering, Boston University, Boston, MA 02215 olga.kovalchuk@uleth.ca ccantor5@gmail.com.
Olga KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4; olga.kovalchuk@uleth.ca ccantor5@gmail.com.
University of Lethbridge · CAUniversity of Michigan–Ann Arbor · USBoston University · US

Funding

CIHR
6 · The paper itself

Abstract

It remains unknown whether microRNA (miRNA/miR) can target transfer RNA (tRNA) molecules. Here we provide evidence that miR-34a physically interacts with and functionally targets tRNA

Indexed as

ApoptosisGene Expression Regulation, NeoplasticRNA Processing, Post-TranscriptionalArgonaute ProteinsBreast NeoplasmsCell CycleFemaleHumansMCF-7 CellsMicroRNAsNeoplasm ProteinsRNA, NeoplasmRNA PrecursorsRNA, Transfer, MetAGO2 protein, humanArgonaute ProteinsMicroRNAsMIRN34 microRNA, humanNeoplasm ProteinsRNA, NeoplasmRNA PrecursorsRNA, Transfer, Metapoptosiscell cyclemiR-34aproliferationtRNAiMet

Identifiers

PMID29941603
PMCPMC6048500
OpenAlexW2810495302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.