Evidence map›Paper›PMID 29941597›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB.

Ben Johnson, Ashley N Leek, Laura Solé, Emily E Maverick, Tim P Levine, Michael M Tamkun

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Nanoscale CabioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  8. Cytoskeletal scaffolding of NaCurrent opinion in cell biology · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  16. Review
  17. Kv2.1 negatively regulates Reissner fiber development.Frontiers in cell and developmental biology · 2025
    Article
  18. Glucocorticoids Rapidly Modulate CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  19. Article
  20. Review

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ben JohnsonDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Ashley N LeekDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Laura SoléDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Emily E MaverickDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
Tim P LevineInstitute of Ophthalmology, University College London Institute of Ophthalmology, London EC1V 9EL, United Kingdom.ORCID 0000-0002-7231-0775
Michael M TamkunDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523; michael.tamkun@colostate.edu.

Funding

Structural and Functional Interactions within the Neuronal ER/PM JunctionR01GM109888 · NIGMS · COLORADO STATE UNIVERSITY · PI BEAM, KURT G, KRAFT, MARY L · 2014 to 2017
$1.5M
Biotechnology and Biological Sciences Research Council BB/M011801/1Biotechnology and Biological Sciences Research Council BB/P003818/1NIGMS NIH HHS R01 GM109888
6 · The paper itself

Abstract

Kv2.1 exhibits two distinct forms of localization patterns on the neuronal plasma membrane: One population is freely diffusive and regulates electrical activity via voltage-dependent K

Indexed as

AnimalsBiotinylationCell MembraneEndoplasmic ReticulumHEK293 CellsHippocampusHumansProtein TransportRatsShab Potassium ChannelsVesicular Transport ProteinsShab Potassium ChannelsVAPA protein, humanVAPB protein, humanVesicular Transport ProteinsER/PM junctionsKv2.1Kv2.2subsurface cisternaeVAP

Identifiers

PMID29941597
PMCPMC6077746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.