Evidence map›Paper›PMID 29941589›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structure of the Lassa virus glycan shield provides a model for immunological resistance.

Yasunori Watanabe, Jayna Raghwani, Joel D Allen, Gemma E Seabright, Sai Li, Felipe Moser, Juha T Huiskonen, Thomas Strecker, Thomas A Bowden, Max Crispin

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 124 citations in OpenAlex.

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  15. Strategies of rational and structure-driven vaccine design for Arenaviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024
    Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Yasunori WatanabeOxford Glycobiology Institute, Department of Biochemistry, University of Oxford, OX1 3QU Oxford, United Kingdom.
Jayna RaghwaniBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7LF Oxford, United Kingdom.
Joel D AllenCentre for Biological Sciences and Institute of Life Sciences, University of Southampton, SO17 1BJ Southampton, United Kingdom.
Gemma E SeabrightOxford Glycobiology Institute, Department of Biochemistry, University of Oxford, OX1 3QU Oxford, United Kingdom.
Sai LiDivision of Structural Biology, University of Oxford, OX3 7BN Oxford, United Kingdom.ORCID 0000-0002-9353-0355
Felipe MoserDivision of Structural Biology, University of Oxford, OX3 7BN Oxford, United Kingdom.
Juha T HuiskonenDivision of Structural Biology, University of Oxford, OX3 7BN Oxford, United Kingdom.
Thomas StreckerInstitute of Virology, Philipps Universität Marburg, 35043 Marburg, Germany.
Thomas A BowdenDivision of Structural Biology, University of Oxford, OX3 7BN Oxford, United Kingdom; thomas.bowden@strubi.ox.ac.uk max.crispin@soton.ac.uk.ORCID 0000-0002-8066-8785
Max CrispinCentre for Biological Sciences and Institute of Life Sciences, University of Southampton, SO17 1BJ Southampton, United Kingdom; thomas.bowden@strubi.ox.ac.uk max.crispin@soton.ac.uk.
University of Oxford · GBUniversity of Southampton · GBPhilipps University of Marburg · DEUniversity of Helsinki · FI

Funding

Support Component D/Vaccine Discovery, Concept to ClinicUM1AI100663 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BAROUCH, DAN H. · 2012 to 2018
$131.5M
Medical Research Council MR/L009528/1Medical Research Council MR/N002091/1NIAID NIH HHS UM1 AI100663Wellcome TrustWellcome Trust 060208/Z/00/ZWellcome Trust 093305/Z/10/ZWellcome Trust 107652/Z15/ZWellcome Trust 203141/Z/16/Z
6 · The paper itself

Abstract

Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. Vaccine development has focused on the envelope glycoprotein complex (GPC) that extends from the virion envelope. The often inadequate antibody immune response elicited by both vaccine and natural infection has been, in part, attributed to the abundance of

Indexed as

GlycosylationLassa virusOligosaccharidesViral Envelope Proteinsglycoprotein gp1, lassa virusglycoprotein gp2, lassa virusOligosaccharidesViral Envelope ProteinsarenavirusglycoproteinglycosylationLassa virusstructure

Identifiers

PMID29941589
PMCPMC6048489
OpenAlexW2811309379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.