ArticleProceedings of the National Academy of Sciences of the United States of America2018
Changes in brain architecture are consistent with altered fear processing in domestic rabbits.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Comprehensive transcriptomics comparison reveals switch of gene networks in the brain during silkworm domestication.Insect science · 2026Article
- Article
- Brain-Behavior Differences in Premodern and Modern Lineages of Domestic Dogs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Whole-Genome Sequencing-Based Population Genetic Analysis of Wild and Domestic Rabbit Breeds.Animals : an open access journal from MDPI · 2025Article
- The quantitative anatomy of the hippocampal formation in homing pigeons and other pigeon breeds: implications for spatial cognition.Brain structure & function · 2024Article
- Helping Rabbits Cope with Veterinary Acts and Vaccine-Related Stress: The Effects of the Rabbit Appeasing Pheromone (RAP).Animals : an open access journal from MDPI · 2024Article
- Association of tameness and sociability but no sign of domestication syndrome in mice selectively bred for active tameness.Genes, brain, and behavior · 2024Article
- The endangered brain: actively preservingRoyal Society open science · 2023Review
- Shared reproductive disruption, not neural crest or tameness, explains the domestication syndrome.Proceedings. Biological sciences · 2023Review
- The Australasian dingo archetype: de novo chromosome-length genome assembly, DNA methylome, and cranial morphology.GigaScience · 2023Article
- The Australasian dingo archetype:bioRxiv : the preprint server for biology · 2023Article
- Cranial shape variation in domestication: A pilot study on the case of rabbits.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- The mammalian brain under domestication: Discovering patterns after a century of old and new analyses.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication.National science review · 2022Article
- A single introduction of wild rabbits triggered the biological invasion of Australia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp (Carassius gibelio).Science China. Life sciences · 2022Article
- The cerebellar anatomy of red junglefowl and white leghorn chickens: insights into the effects of domestication on the cerebellum.Royal Society open science · 2021Article
- Positive selection of skeleton-related genes during duck domestication revealed by whole genome sequencing.BMC ecology and evolution · 2021Article
- Intensive human contact correlates with smaller brains: differential brain size reduction in cattle types.Proceedings. Biological sciences · 2021Article
- A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits.PLoS genetics · 2021Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial prefrontal cortex volume, supporting that areas driving fear have lost volume while areas modulating negative affect have gained volume during domestication. In contrast to the localized gray matter alterations, white matter anisotropy was reduced in the corona radiata, corpus callosum, and the subcortical white matter. This suggests a compromised white matter structural integrity in projection and association fibers affecting both afferent and efferent neural flow, consistent with reduced neural processing. We propose that compared with their wild ancestors, domestic rabbits are less fearful and have an attenuated flight response because of these changes in brain architecture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.