Evidence map›Paper›PMID 29941491›Full record

ReviewMolecular and cellular biology2018

Centromere Biology: Transcription Goes on Stage.

Carlos Perea-Resa, Michael D Blower

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
11.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Preserving centromere identity: right amounts of CENP-A at the right place and time.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation and homologous recombination repair.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Unique Features of Satellite DNA Transcription in Different Tissues ofInternational journal of molecular sciences · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Carlos Perea-ResaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael D BlowerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA blower@molbio.mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · US

Funding

Transcriptome regulation during mitosisR01GM122893 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI BLOWER, MICHAEL DEMIAN · 2017 to 2023
$2.0M
NIGMS NIH HHS R01 GM122893
6 · The paper itself

Abstract

Accurate chromosome segregation is a fundamental process in cell biology. During mitosis, chromosomes are segregated into daughter cells through interactions between centromeres and microtubules in the mitotic spindle. Centromere domains have evolved to nucleate formation of the kinetochore, which is essential for establishing connections between chromosomal DNA and microtubules during mitosis. Centromeres are typically formed on highly repetitive DNA that is not conserved in sequence or size among organisms and can differ substantially between individuals within the same organism. However, transcription of repetitive DNA has emerged as a highly conserved property of the centromere. Recent work has shown that both the topological effect of transcription on chromatin and the nascent noncoding RNAs contribute to multiple aspects of centromere function. In this review, we discuss the fundamental aspects of centromere transcription, i.e., its dual role in chromatin remodeling/CENP-A deposition and kinetochore assembly during mitosis, from a cell cycle perspective.

Indexed as

Transcription, GeneticAnimalsAurora Kinase BCentromereCentromere Protein AChromatin Assembly and DisassemblyChromosome SegregationDNAHumansKinetochoresMitosisModels, GeneticRNA, NuclearRNA Polymerase IIAurora Kinase BCentromere Protein ADNARNA, NuclearRNA Polymerase IIAurora-BCENP-ACENP-CcenRNAcentromerecentromere transcriptionchromosome segregationCPCmitosisncRNAR-loopRNA Pol II

Identifiers

PMID29941491
PMCPMC6113603
OpenAlexW2809085841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.