Evidence map›Paper›PMID 29941462›Full record

ArticleInfection and immunity2018

High Mobility Group Protein 1 Reverses Immune System Paralysis in Late-Phase Sepsis.

Qing-Yang Liu, Yue-Xin Wang, Zong-Sheng Wu, Zhen-Wei Shi, Xu Wu, Xin Chen, Zhao Yang, Kai-Zhi Xu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Qing-Yang LiuDepartment of Translational Medicine and Nephrology, China Meitan General Hospital, Beijing, China qingyangliu_ccm@sina.com xukaizhi195601@163.com.
Yue-Xin WangFirst Department of Orthopedics, Tangshan Worker's Hospital Affiliated to Hebei Medical University, Tangshan, Hebei Province, China.
Zong-Sheng WuDepartment of Emergency, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.
Zhen-Wei ShiDepartment of Translational Medicine and Nephrology, China Meitan General Hospital, Beijing, China.
Xu WuBecton-Dickinson Biosciences, Beijing, China.
Xin ChenDepartment of Oncology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Zhao YangCollege of Chemistry, Beijing Normal University, Beijing, China.
Kai-Zhi XuDepartment of Anesthesiology, Tangshan Worker's Hospital Affiliated to Hebei Medical University, Tangshan, Hebei Province, China qingyangliu_ccm@sina.com xukaizhi195601@163.com.
Liaoning Provincial People's Hospital · CNBeijing Normal University · CNChinese PLA General Hospital · CNHuazhong University of Science and Technology · CNMeitan General Hospital · CNZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High mobility group protein 1 (HMGB1) is considered to be the primary inflammatory factor triggering immune paralysis in late-phase sepsis. In this study, however, we wanted to explore the possibility of using HMGB1 to boost local differentiation of bone marrow cells (BMCs) into regulatory dendritic cells (DCs)

Indexed as

Adoptive TransferAnimalsBone Marrow CellsCecumCell DifferentiationDendritic CellsDisease Models, AnimalHMGB1 ProteinLigationMice, Inbred C3HMice, Inbred C57BLParabiosisPneumoniaPseudomonas aeruginosaPseudomonas InfectionsSepsisHMGB1 ProteinTlr4 protein, mouseToll-Like Receptor 4bone marrow cellsCD11c− CD45RBhigh dendritic cellshigh mobility group protein 1sepsis

Identifiers

PMID29941462
PMCPMC6105879
OpenAlexW2810750101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.