Evidence map›Paper›PMID 29941456›Full record

ArticleThe Journal of biological chemistry2018

Mechanism of premature translation termination on a sense codon.

Egor Svidritskiy, Gabriel Demo, Andrei A Korostelev

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  12. Cryo-EM as a powerful tool for drug discovery.Bioorganic & medicinal chemistry letters · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Egor SvidritskiyFrom the RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Gabriel DemoFrom the RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Andrei A KorostelevFrom the RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605 andrei.korostelev@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

Molecular principles of translation terminationR01GM107465 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOROSTELEV, ANDREI · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM107465
6 · The paper itself

Abstract

Accurate translation termination by release factors (RFs) is critical for the integrity of cellular proteomes. Premature termination on sense codons, for example, results in truncated proteins, whose accumulation could be detrimental to the cell. Nevertheless, some sense codons are prone to triggering premature termination, but the structural basis for this is unclear. To investigate premature termination, we determined a cryo-EM structure of the

Indexed as

Peptide Chain Termination, TranslationalCodonCodon, TerminatorCrystallography, X-RayEscherichia coliEscherichia coli ProteinsPeptide Termination FactorsProtein ConformationRibosomesCodonCodon, TerminatorEscherichia coli ProteinsPeptide Termination Factors70S ribosomehot-spot sense codonhydrophobic interactionsnear-stop codonribosome functionribosome structureRNA–protein interactiontranslation regulationtranslation release factorπ-stacking

Identifiers

PMID29941456
PMCPMC6093235
OpenAlexW2809717247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.