SynthesisOrphanet journal of rare diseases2018
Thymectomy in nonthymomatous myasthenia gravis - systematic review and meta-analysis.
Synthesis in Orphanet journal of rare diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effects of thymectomy on late-onset non-thymomatous myasthenia gravis: systematic review and meta-analysis.Orphanet journal of rare diseases · 2021Pooled it
- Prevalence and risk factors of myasthenia gravis recurrence post-thymectomy.Neurosciences (Riyadh, Saudi Arabia) · 2021Pooled it
- Minimally invasiveJournal of thoracic disease · 2025Article
- Outcomes of Treatment in Ocular Myasthenia Gravis Based on Minimal Manifestation: A Real-World Retrospective Cohort Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Uniportal video-assisted thoracoscopic thymectomy in Hospital Kuala Lumpur: a retrospective observational review of outcomes for patients diagnosed with thymomatous and non-thymomatous myasthenia gravis.Journal of thoracic disease · 2024Article
- Thymoma negatively affects the neurological outcome of myasthenia gravis after thymectomy: a propensity score matching study.Journal of cardiothoracic surgery · 2024Article
- Physiological and pathological roles of the thymus and value of thymectomy in myasthenia gravis: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
- Outcomes after thymectomy in non-thymomatous myasthenia gravis.Journal of thoracic disease · 2023Article
- Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients.International journal of environmental research and public health · 2023Article
- Clinical characteristics of myasthenia gravis (MG) patients developing other autoimmune diseases after thymectomy from one single center cohort.Thoracic cancer · 2023Article
- Assessment of length of stay and cost of minimally invasive versus open thymectomies in patients with myasthenia gravis in Florida.Gland surgery · 2022Article
- Thymectomy and Risk of Generalization in Patients with Ocular Myasthenia Gravis: A Multicenter Retrospective Cohort Study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- The mitochondrial biogenesis signaling pathway is a potential therapeutic target for myasthenia gravis via energy metabolism (Review).Experimental and therapeutic medicine · 2021Review
- Myasthenia gravis presenting as bilateral pseudointernuclear ophthalmoplegia in a patient with an incidental prolactinoma.BMJ case reports · 2020Article
- Who will benefit from thymectomy for myasthenia gravis? Is there any role for this procedure in elderly patients?Annals of translational medicine · 2019Article
- Thymus pathology in myasthenia gravis with anti-acetylcholine receptor antibodies and concomitant Hashimoto's thyroiditis. A four-case series and literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- The Clinical Outcome in AChR-Positive Generalized Myasthenia Gravis: A Retrospective Observational Study.Annals of Indian Academy of NeurologyArticle
- Thymectomy in Myasthenia Gravis: A Narrative Review.Saudi journal of medicine & medical sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study is to evaluate by means of a systematic review, the efficacy of thymectomy as compared to medical treatment for non-thymomatous myasthenia gravis (MG).
methodsMedline, Embase, and Lilacs were searched for experimental and observational studies that compared non-surgical (drug therapy) and surgical treatment of non-thymomatous MG (thymectomy performed by the transsternal approach). Inclusion criteria were: studies that compared the two types of treatment and had at least 10 adult patients in each group. Exclusion criteria were articles published before 1970, as well as those that included patients treated before 1950. The outcomes evaluated were: remission, and improvement rates. RevMan 5.3 software provided by the Cochrane Collaboration was used. When the heterogeneity between the studies was greater than 75%, a meta-analysis was not performed according to RevMan guidelines.
resultsThe total number of patients evaluated in 19 articles selected was 5841 (2911 surgical and 2930 non-surgical). Two included randomized clinical trials showed superiority of the surgical treatment over the non-surgical. Four retrospective studies with 379 patients paired by gender, age, and other confounders, also showed superiority of surgical treatment (OR 4.10, 95% CI 2.25 to 7.44; I
conclusionThymectomy may be considered effective in the treatment for non-thymomatous MG, with remission rate higher than for non-surgical treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.