ArticleCardiovascular ultrasound2018
Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study.
Article in Cardiovascular ultrasound, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07131111 (Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta
Who cites it
2 citing papers in PubMed.
- Increased prevalence of left ventricular diastolic dysfunction in adults with repaired coarctation of aorta.International journal of cardiology. Heart & vasculature · 2020Article
- Assessment of Aortic Stiffness by Transthoracic Echocardiographic in Young COVID-19 Patients.Journal of cardiovascular echographyArticle
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients who underwent a successful repair of the aortic coarctation (CoA) show high risk for cardiovascular (CV) events. Mechanical and structural abnormalities in the ascending aorta (Ao) might have a role in the prognosis of CoA patients. We analyzed the elastic properties of Ao measured as aortic stiffness index (AoSI) in CoA patients in the long-term period and we compared AoSI with a cohort of 38 patients with rheumatoid arthritis (RA) and 38 non-RA matched controls.
methodsData from 19 CoA patients were analyzed 28 ± 13 years after surgery. Abnormally high AoSI was diagnosed if AoSI > 6.07% (95th percentile of the AoSI detected in our reference healthy population). AoSI was assessed at the level of the aortic root by two-dimensional guided M-mode evaluation.
resultsCoA patients showed more than two-fold higher AoSI compared to RA and controls (9.8 ± 12.6 vs 4.8 ± 2.5% and 3.1 ± 2.0%, respectively; all p < 0.05 and in 5 of 19 patients with CoA (26%) AoSI was exceptionally high. The 5 patients with abnormally high AoSI were older with higher BP, LV mass and prevalence of LV diastolic dysfunction. Multiple linear regression analysis revealed that AoSI was independently related to the presence of LV hypertrophy and higher LV relative wall thickness.
conclusionsCoA patients have higher AoSI levels than RA patients and non-RA matched controls. AoSI levels are abnormally high in a small sub-group of CoA patients who show a very high-risk clinical profile for adverse CV events.
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