Observational studyBMC cardiovascular disorders2018
Admission homocysteine is an independent predictor of spontaneous reperfusion and early infarct-related artery patency before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction.
Observational study in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Associated factors of spontaneous reperfusion in patients with acute ST-segment elevation myocardial infarction before primary percutaneous coronary intervention.African health sciences · 2025Article
- Association between uric acid-albumin ratio and spontaneous reperfusion in ST-segment elevation myocardial infarction patients.Journal of geriatric cardiology : JGC · 2025Article
- Differential gene expression patterns in ST-elevation Myocardial Infarction and Non-ST-elevation Myocardial Infarction.Scientific reports · 2024Article
- Circulating Cytokines in Myocardial Infarction Are Associated With Coronary Blood Flow.Frontiers in immunology · 2022Article
- Relationship Between Plasma Total Homocysteine Levels and Mean Corrected TIMI Frame Count in Patients with Acute Myocardial Infarction.International journal of general medicine · 2021Article
- Article
- Red Cell Distribution Width/Albumin Ratio as a Valuable Marker to Predict Spontaneous Recanalization in Acute ST-Segment Elevation Myocardial Infarction: A Retrospective Cohort Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpontaneous reperfusion (SR) and early infarct related artery (IRA) patency before primary percutaneous coronary intervention (PPCI) might bring extra benefit for patients with ST-segment elevation myocardial infarction (STEMI). This study premilinarily screened the independent predictors of SR, and assessed the relationship between SR and plasma homocysteine (HCY).
methodsThe medical records of 998 patients who were diagnosed as STEMI and underwent emergency coronary angiography were retrospectively studied, SR was defined as achievement of TIMI grade 3 flow in the IRA before PCI. The baseline characteristics, clinical manifestations and hematological variables were compared between SR and NSR group. Optimal cutoff point of HCY was calculated with receiving operating characteristics (ROC) analysis, multivariate logistic regression models were used to identify predictors of SR.
results229 (22.95%) patients showed angiographic SR. For HCY, the area under the curve was 0.70 (95% CI: 0.63-0.77, P = 0.034), the optimized cut off point was 17.55 μmol/L. Preinfarct angina (95% CI: 1.61-5.65, P = 0.0005), plasma C-reactive protein (CRP) level (95% CI: 0.87-0.99, P = 0.016) and HCY < 17.55 μmol/L (95% CI: 2.43-8.72, P < 0.0001) were found to be independent predictors for SR.
conclusionIn patients with STEMI, HCY < 17.55 μmol/L, preinfarct angina and plasma CRP level were independent predictors of SR.
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