ArticleBMC pregnancy and childbirth2018
Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study.
Article in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Prevalence and Predictors of Gestational Diabetes Mellitus in Sub-Saharan Africa: A 10-Year Systematic Review.Endocrinology, diabetes & metabolism · 2024Pooled it
- Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Incidence and trend of preterm birth in China, 1990-2016: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.Annals of the New York Academy of Sciences · 2019Pooled it
- Association between high maternal haemoglobin levels in the first trimester and gestational diabetes mellitus: a prospective birth cohort study.Journal of global health · 2026Article
- Haemoglobin Concentrations and Maternal and Neonatal Outcomes: Identifying Optimal Haemoglobin Ranges.Paediatric and perinatal epidemiology · 2026Article
- Maternal cardiometabolic dysfunction and fetal sex-specific alterations to uterine vascular reactivity in an ovine model of obesity during pregnancy.The Journal of physiology · 2026Article
- Associations of maternal hemoglobin and its changes with gestational diabetes mellitus: a prospective cohort study.Nutrition journal · 2026Article
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Prenatal Disorders.Acta medica Philippina · 2026Article
- The construction and validation of a prediction model of hypertensive disease in pregnancy.Scientific reports · 2025Article
- Article
- Impact of physical activity on maternal and neonatal outcomes among women with vaginal births-single center prospective cohort study.Frontiers in medicine · 2025Article
- Risk Factors for Gestational Diabetes Mellitus in Mainland China: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Hemoglobin concentrations in early pregnancy and their associations with adverse pregnancy outcomes in Western China: a population-based study.BMC pregnancy and childbirth · 2024Article
- Biochemical Markers in the Prediction of Pregnancy Outcome in Gestational Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2024Article
- First-trimester hemoglobin, haptoglobin genotype, and risk of gestational diabetes mellitus in a retrospective study among Chinese pregnant women.Nutrition & diabetes · 2024Article
- Anaemia at mid-pregnancy is associated with prehypertension in late pregnancy among urban women.Health SA = SA Gesondheid · 2024Article
- Article
- Vitamins and minerals, education, and self-care need during preconception to 1000 days of life in Southeast Asia: An expert panel opinion.SAGE open medicine · 2023Review
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10 authors.
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Abstract
backgroundHemoglobin (Hb) measurement is a standard test among pregnant women during the first perinatal visit that is used to evaluate physical status and anemia. However, studies focusing on Hb levels and pregnancy outcomes are scarce. This study aimed to determine whether Hb levels in early pregnancy were associated with the risk of gestational diabetes mellitus (GDM), pre-eclampsia (PE) and preterm birth.
methodsA hospital-based retrospective study was conducted among 21,577 singleton, non-smoking pregnancies between June 2013 and January 2015. The demographic data and medical information of each participant were collected individually through questionnaires and patient medical records. Odds ratios were generated using a multivariate logistic regression analysis to evaluate the relative risk of GDM, PE and preterm birth continuously and across different hemoglobin ranges in the overall population and in women from different pre-pregnancy body mass index (BMI) categories, respectively. The level of statistical significance was set at 0.05.
results(1) For women who were underweight, normal-weight, overweight and obese, early pregnancy Hb levels were 127.8 ± 10.1 g/L, 129.6 ± 9.7 g/L, 132.2 ± 9.5 g/L and 133.4 ± 9.4 g/L, respectively. (2) Women with GDM and PE had significantly increased Hb levels during early pregnancy compared with controls, whereas women with preterm birth processed significantly decreased Hb levels. (3) After adjusting for confounders, the risks for GDM and PE increased with high maternal Hb (OR: 1.27 for Hb 130-149; OR: 2.06 for Hb ≥ 150 g/L), and the risk for preterm birth decreased with high maternal Hb (OR: 1.30 for Hb 130-149; OR: 2.38 for Hb ≥ 150 g/L) and increased with low maternal Hb (OR: 1.41 for Hb < 110 g/L). Among women whose BMI was < 24 kg/m
conclusionThese findings suggest that Hb levels during early pregnancy play a role in predicting the risk of GDM, PE and preterm birth.
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