ArticleBMC plant biology2018
Multiple morphogenic culture systems cause loss of resistance to cassava mosaic disease.
Article in BMC plant biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Reinfection Dynamics of Disease-Free Cassava Plants in Three Agroecological Regions of Côte d'Ivoire.Viruses · 2025Article
- Genetic complexity of cassava brown streak disease: insights from qPCR-based viral titer analysis and genome-wide association studies.Frontiers in plant science · 2024Article
- Mutations in DNA polymerase δ subunit 1 co-segregate with CMD2-type resistance to Cassava Mosaic Geminiviruses.Nature communications · 2022Article
- CRISPR-Cas9-mediated knockout ofFrontiers in plant science · 2022Article
- Studies on Pure MlbFrontiers in plant science · 2022Article
- Genome Editing for Sustainable Agriculture in Africa.Frontiers in genome editing · 2022Review
- Efficient Genetic Transformation and Regeneration of a Farmer-Preferred Cassava Cultivar From Ghana.Frontiers in plant science · 2021Article
- Deeply Sequenced Infectious Clones of Key Cassava Begomovirus Isolates from Cameroon.Microbiology resource announcements · 2020Article
- In vitro propagation of three mosaic disease resistant cassava cultivars.BMC biotechnology · 2020Article
- Host Plant Strategies to Combat Against Viruses Effector Proteins.Current genomics · 2020Review
- Geminivirus Resistance: A Minireview.Frontiers in plant science · 2020Review
- Engineering Disease-Resistant Cassava.Cold Spring Harbor perspectives in biology · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundMorphogenic culture systems are central to crop improvement programs that utilize transgenic and genome editing technologies. We previously reported that CMD2-type cassava (Manihot esculenta) cultivars lose resistance to cassava mosaic disease (CMD) when passed through somatic embryogenesis. As a result, these plants cannot be developed as products for deployment where CMD is endemic such as sub-Saharan Africa or the Indian sub-continent.
resultIn order to increase understanding of this phenomenon, 21 African cassava cultivars were screened for resistance to CMD after regeneration through somatic embryogenesis. Fifteen cultivars were shown to retain resistance to CMD through somatic embryogenesis, confirming that the existing transformation and gene editing systems can be employed in these genetic backgrounds without compromising resistance to geminivirus infection. CMD2-type cultivars were also subjected to plant regeneration via caulogenesis and meristem tip culture, resulting in 25-36% and 5-10% of regenerated plant lines losing resistance to CMD respectively.
conclusionsThis study provides clear evidence that multiple morphogenic systems can result in loss of resistance to CMD, and that somatic embryogenesis per se is not the underlying cause of this phenomenon. The information described here is critical for interpreting genomic, transcriptomic and epigenomic datasets aimed at understanding CMD resistance mechanisms in cassava.
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