Evidence map›Paper›PMID 29940854›Full record

ArticleBMC immunology2018

Rapid loss of early antigen-presenting activity of lymph node dendritic cells against Ag85A protein following Mycobacterium bovis BCG infection.

Zhengzhong Xu, Aihong Xia, Xin Li, Zhaocheng Zhu, Yechi Shen, Shanshan Jin, Tian Lan, Yuqing Xie, Han Wu, Chuang Meng and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Can miRNA Indicate Risk of Illness after Continuous Exposure toInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Zhengzhong XuJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China.
Aihong XiaJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China.
Xin LiJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China.
Zhaocheng ZhuJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China.
Yechi ShenKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.
Shanshan JinKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.
Tian LanKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.
Yuqing XieKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.
Han WuKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.
Chuang MengJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China.
Lin SunJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China.
Yuelan YinKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.
Xiang ChenJiangsu Key Laboratory of Zoonosis, Yangzhou University, No. 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, China. chenxiang@yzu.edu.cn.
Xinan JiaoKey Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China. jiao@yzu.edu.cn.
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundControl of Mycobacterium tuberculosis (Mtb) infection requires CD4

resultsIn the present study, we evaluated in vivo dynamics of early Ag presentation by murine lymph-node (LN) DCs in response to Mycobacterium bovis bacillus Calmette-Guérin (BCG) Ag85A protein. Results showed that the early Ag-presenting activity of murine DCs induced by M. bovis BCG Ag85A protein in vivo was transient, appearing at 4 h and being barely detectable at 72 h. The transcription levels of CIITA, MHC II and the expression of MHC II molecule on the cell surface increased following BCG infection. Moreover, BCG was found to survive within the inguinal LN DC pool, representing a continuing source of mycobacterial Ag85A protein, with which LN DCs formed Ag85A peptide-MHCII complexes in vivo.

conclusionsOur results demonstrate that a decrease in Ag85A peptide production as a result of the inhibition of Ag processing to is largely responsible for the short duration of Ag presentation by LN DCs during BCG infection in vivo.

Indexed as

AcyltransferasesAdjuvants, ImmunologicAnimalsAntigen PresentationAntigens, BacterialBCG VaccineCell SurvivalDendritic CellsHistocompatibility Antigens Class IIInterferon-gammaLymph NodesMice, Inbred C57BLMycobacterium bovisTime FactorsTuberculosisAcyltransferasesAdjuvants, Immunologicantigen 85A, Mycobacterium tuberculosisAntigens, BacterialBCG VaccineHistocompatibility Antigens Class IIInterferon-gammaAg-presenting activityDendritic cellIn vivoMajor histocompatibility complex class IIM. bovis BCG

Identifiers

PMID29940854
PMCPMC6019797
OpenAlexW2810813050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.