Evidence map›Paper›PMID 29940720›Full record

ArticleClinical and molecular hepatology2018

Effect of antiviral therapy in reducing perinatal transmission of hepatitis B virus and maternal outcomes after discontinuing them.

Kwang Il Seo, Si Hyun Bae, Pil Soo Sung, Chung-Hwa Park, Hae Lim Lee, Hee Yeon Kim, Hye Ji Kim, Bo Hyun Jang, Jeong Won Jang, Seung Kew Yoon and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and molecular hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Kwang Il SeoDepartment of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Si Hyun BaeDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Pil Soo SungDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Chung-Hwa ParkDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Hae Lim LeeDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Hee Yeon KimDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Hye Ji KimDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Bo Hyun JangDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Jeong Won JangDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Seung Kew YoonDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Jong Young ChoiDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
In-Yang ParkDepartment of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
Juyoung LeeDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyun Seung LeeDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sa-Jin KimDepartment of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
Jung Hyun KwonDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
U Im ChangDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Chang Wook KimDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Se Hyun JoDepartment of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Young LeeDepartment of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
Fisseha TekleDepartment of Gastroentrology and Hepatology, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Jong-Hyun KimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic University of Korea · KRKosin University · KRSt. Paul's Hospital Millennium Medical College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThere have been numerous efforts to reduce mother-to-child transmission (MTCT) of hepatitis B virus (HBV) with antiviral agents during pregnancy. However, there are limited data regarding the outcomes of pregnant women after delivery. This study was performed to evaluate the efficacy of antiviral agents in preventing MTCT of HBV and maternal long-term outcomes.

methodsThe HBV-infected pregnant women treated with antiviral agents to prevent MTCT were retrospectively reviewed. Forty-one pregnant women who received telbivudine or tenofovir during late pregnancy (28-34 week) were analyzed. Hepatitis B virus surface antibody (HBsAb) positivity was tested in 43 infants after 7 months of birth. Eleven mothers were followed >1 year after delivery.

resultsThe mean HBV DNA titer before antiviral therapy was 8.67 (6.60-9.49) log copies/mL, and the median age at delivery was 32 years (range, 22-40). Eleven patients were treated with tenofovir and 30 with telbivudine. The median duration was 57 days (range, 23-100), and the median HBV DNA titer at birth was 5.06 log copies/mL (range, 2.06-6.50). Antiviral treatments were associated with significant HBV DNA reduction (P<0.001). Among 43 infants (two cases of twins), HBsAb was not detected in two, subsequently confirmed to have HBV infection. Biochemical flare was observed in two of 11 mothers followed >12 months, and an antiviral agent was administered.

conclusionAntiviral treatment during late pregnancy effectively reduced MTCT. Long-term follow-up should be required in such cases. In addition, given that maternal biochemical flare occurred in 18% of mothers, re-administration of antiviral agents might be required.

Indexed as

AdultAntiviral AgentsDNA, ViralFemaleHepatitis B AntibodiesHepatitis B, ChronicHepatitis B virusHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalPostpartum PeriodPregnancyRetrospective StudiesTelbivudineTenofovirAntiviral AgentsDNA, ViralHepatitis B AntibodiesTelbivudineTenofovirAntiviral agentsHepatitis B virusMother-to-child transmissionPostpartumPregnancy

Identifiers

PMID29940720
PMCPMC6313021
OpenAlexW2810971097

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.