ArticlePsychoneuroendocrinology2018
Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study.
Article in Psychoneuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame.Molecular psychiatry · 2024Trial
- Role of Oxytocin in Obesity.Current diabetes reports · 2026Review
- Deconvolution-Based Transcriptomic Analysis in the Hippocampus Reveals Cell Type-Specific Risk Genes and Pathways Associated With Depression and Suicide.Biological psychiatry global open science · 2025Article
- Pleiotropic effects of oxytocin receptor polymorphisms: influencing striatocortical connectivity in bipolar disorder.International journal of bipolar disorders · 2025Article
- Mediating Impact of Intranasal Oxytocin on the Interaction Between Irritability and Reactive Aggression in Youth with Severe Irritability.Life (Basel, Switzerland) · 2025Article
- Near-infrared spectroscopic study of blood flow changes in the dorsolateral prefrontal cortex during pain relief by odor stimulation.Biophysics and physicobiology · 2025Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders.Stem cell reviews and reports · 2023Article
- Intertwined associations between oxytocin, immune system and major depressive disorder.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Review
- Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023Review
- Oxytocin receptor expression patterns in the human brain across development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Oxytocin receptor gene methylation as a molecular marker for severity of depressive symptoms in affective disorder patients.BMC psychiatry · 2022Article
- Gene Expression Profiling of the Habenula in Rats Exposed to Chronic Restraint Stress.Molecules and cells · 2022Article
- Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.Autonomic neuroscience : basic & clinical · 2022Article
- OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study.Journal of molecular neuroscience : MN · 2022Article
- Regulation of oxytocin receptor gene expression in obsessive-compulsive disorder: a possible role for the microbiota-host epigenetic axis.Clinical epigenetics · 2022Article
- Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity.Developmental psychobiology · 2022Article
- Multiple Aspects of Inappropriate Action of Renin-Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases.Journal of clinical medicine · 2022Review
- Dorsolateral prefrontal cortex sensing analgesia.Biophysics and physicobiology · 2022Article
- Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.Clinical epigenetics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
There is growing interest in oxytocin as a putative treatment for various psychiatric disorders including major depressive disorder, bipolar disorder and schizophrenia/schizoaffective disorder. However, potential alterations in the endogenous brain oxytocin system in these disorders are poorly characterized. Brain expression of oxytocin and its receptor genes in patients with these psychiatric disorders has not been well studied outside the hypothalamus. We measured expression of mRNA for oxytocin and its receptor in the dorsolateral prefrontal cortex of postmortem brains using quantitative polymerase chain reaction in a total of 581 individuals. These individuals either were diagnosed with major depressive disorder (n = 135), bipolar disorder (n = 57), schizophrenia/schizoaffective disorder (n = 169), or were control subjects, defined as individuals with no lifetime history of any of these disorders (n = 220). Diagnoses of major depressive disorder and bipolar disorder were associated with significantly increased oxytocin receptor mRNA levels in the dorsolateral prefrontal cortex. This finding is discussed in light of the extant literature on the dysregulation of oxytocin signaling in individuals with major psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.