Evidence map›Paper›PMID 29940408›Full record

ReviewMolecular immunology2018

Role of MAIT cells in pulmonary bacterial infection.

Nadine Hartmann, Melanie J Harriff, Curtis P McMurtrey, William H Hildebrand, David M Lewinsohn, Mitchell Kronenberg

Open access · greenAbstract readReview
In one paragraph

Review in Molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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  18. Mucosal-associated invariant T cells: new players in CF lung disease?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nadine HartmannDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, United States.
Melanie J HarriffDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Sciences University, Portland, OR, 97239, United States; VA Portland Health Care System, Portland, OR, 97239, United States.
Curtis P McMurtreyDepartment of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73140, United States; Pure MHC, Oklahoma City, OK, 73104, United States.
William H HildebrandDepartment of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73140, United States; Pure MHC, Oklahoma City, OK, 73104, United States.
David M LewinsohnDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Sciences University, Portland, OR, 97239, United States; VA Portland Health Care System, Portland, OR, 97239, United States.
Mitchell KronenbergDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, United States; Division of Biology, University of California San Diego, La Jolla, CA, 92037, United States. Electronic address: mitch@lji.org.
La Jolla Institute for Immunology · USOregon Health & Science University · USPure Protein (United States) · US

Funding

Development and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9M
Host nutrients permit immune evasion of NKT cell anti-bacterial responsesR01AI137230 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2018 to 2022
$3.1M
Differentiation of subsets of NKT cellsR01AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7M
The role of natural killer T cells in the innate response to lung infectionR01AI105215 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2014 to 2018
$2.2M
Distinct pathways for MR1 antigen presentation upon infection with intracellular versus extracellular pathogensR01AI129976 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HARRIFF, MELANIE J · 2017 to 2021
$1.9M
Recognition of Mtb-Infected Cells by Non-Classically Restritcted CD8+ T CellsI01BX000533 · VA · PORTLAND VA MEDICAL CENTER · PI LEWINSOHN, DAVID M. · 2011 to 2024
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BLRD VA I01 BX000533NIAID NIH HHS R01 AI071922NIAID NIH HHS R01 AI105215NIAID NIH HHS R01 AI129976NIAID NIH HHS R01 AI137230NIAID NIH HHS R37 AI071922
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAIT cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.

Indexed as

AnimalsAnti-Bacterial AgentsAntigen PresentationBacterial InfectionsHumansLungLymphocyte ActivationMucosal-Associated Invariant T CellsAnti-Bacterial AgentsInnate immunityMAIT cellsMR1Pulmonary infection

Identifiers

PMID29940408
PMCPMC6138534
OpenAlexW2810207524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.