ArticleFree radical biology & medicine2018
Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.
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Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31citing papers in PubMed, 1 pooled it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Superoxide Dismutase Administration: A Review of Proposed Human Uses.Molecules (Basel, Switzerland) · 2021Pooled it
- Multifaceted roles of superoxide dismutases (SODs) in cellular homeostasis and cancer progression: Redox regulation and therapeutic implications.Journal of medical biochemistry · 2026Article
- Targeting SOD3-Mediated Oxidative Stress with Betulonic Acid Protects Against Steroid-Induced Femoral Head Necrosis.Drug design, development and therapy · 2026Article
- Glutathione depletion under hypoxia via a birnessite-type manganese oxide nanozyme inducing immunogenic ferroptosis for magnetic resonance imaging guided cancer therapy.Theranostics · 2026Article
- Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative Mechanisms.International journal of molecular sciences · 2025Article
- Free Radicals in Health and Disease.MedComm · 2025Review
- Deletion of Transmembrane protein 184b leads to retina degeneration in mice.Cell proliferation · 2025Article
- Article
- Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline.Frontiers in pharmacology · 2024Review
- Article
- Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies.Redox report : communications in free radical research · 2023Review
- The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics.Antioxidants (Basel, Switzerland) · 2023Review
- Increased Efficiency of a Functional SOD Mimic Achieved with Pyridine Modification on a Pyclen-Based Copper(II) Complex.Inorganic chemistry · 2023Article
- Article
- Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases.Frontiers in immunology · 2023Article
- Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis.Theranostics · 2022Article
- Superoxide dismutase 3 prevents early stage diabetic retinopathy in streptozotocin-induced diabetic rat model.PloS one · 2022Article
- In Vitro Anticancer Activity of Novel Co(II) and Ni(II) Complexes of Non-steroidal Anti-inflammatory Drug Niflumic Acid Against Human Breast Adenocarcinoma MCF-7 Cells.Cell biochemistry and biophysics · 2021Article
- Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome.International ophthalmology · 2021Article
- Modulation of SOD3 Levels Is Detrimental to Retinal Homeostasis.Antioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Katherine J WertByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, United States; Omics Laboratory, Stanford University, Palo Alto, CA, United States.
Gabriel VelezByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, United States; Omics Laboratory, Stanford University, Palo Alto, CA, United States.
Madeline R CrossDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Brett A WagnerDepartment of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Melissa L Teoh-FitzgeraldDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Garry R BuettnerDepartment of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
J Jason McAnanyDepartment of Ophthalmology, University of Illinois at Chicago, Chicago, IL, United States.
Alicia OlivierDivision of Comparative Pathology, Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Stephen H TsangBernard and Shirlee Brown Glaucoma Laboratory and Barbara & Donald Jonas Laboratory of Regenerative Medicine, Columbia University, New York, NY, United States; Edward S. Harkness Eye Institute, Columbia University, New York, NY, United States; Departments of Ophthalmology, Pathology & Cell Biology, and Institute of Human Nutrition, Columbia University, New York, NY, United States.
Matthew M HarperDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, United States; Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA, United States; Veterans Affairs Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, United States.
Frederick E DomannDepartment of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Alexander G BassukDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Vinit B MahajanByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, United States; Omics Laboratory, Stanford University, Palo Alto, CA, United States; Palo Alto Veterans Administration, Palo Alto, CA, United States. Electronic address: vinit.mahajan@stanford.edu.
University of Iowa · USPalo Alto University · USColumbia University · USUniversity of Illinois Chicago · USUniversity of Nebraska Medical Center · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MPulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MTranslational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8MInstrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9MStanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0MToward mechanism- and gene-based therapies for retinal degenerationR01EY018213 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2008 to 2026
$6.6MGene Silencing and Gene Editing in PhototransductionR01EY024698 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2015 to 2026
$4.7MMechanisms of Early Functional Loss in Diabetic Eye DiseaseR01EY026004 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI James JASON McAnany · 2016 to 2026
$4.2MStructure and Function of Calpain-5R01EY024665 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2015 to 2019
$1.9MMechanistic Studies on Regenerative Medicine Approaches to Childhood BlindnessR01EY026682 · NEI · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, MAHAJAN, VINIT B · 2016 to 2019
$1.6MMechanism-based therapies for photoreceptor degenerationR01EY025225 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2015 to 2018
$1.3MNCI NIH HHS P30 CA013696NEI NIH HHS P30 EY001792NEI NIH HHS P30 EY019007NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY018213NEI NIH HHS R01 EY024665NEI NIH HHS R01 EY024698NEI NIH HHS R01 EY025225NEI NIH HHS R01 EY026004NEI NIH HHS R01 EY026682NIA NIH HHS R21 AG050437NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T32 GM007337
Abstract
Oxidative stress is a pathogenic feature in vitreoretinal disease. However, the ability of the inner retina to manage metabolic waste and oxidative stress is unknown. Proteomic analysis of antioxidants in the human vitreous, the extracellular matrix opposing the inner retina, identified superoxide dismutase-3 (SOD3) that localized to a unique matrix structure in the vitreous base and cortex. To determine the role of SOD3, Sod3
Indexed as
AnimalsDiabetic RetinopathyFemaleHumansMaleMiceMice, KnockoutOxidative StressRetinaSuperoxide DismutaseVitreous BodySOD3 protein, humanSod3 protein, mouseSuperoxide DismutaseAntioxidantDiabetic retinopathyExtracellular matrixKnockout mouseMetabolic dysregulationProteomicsVitreous baseVitreous cortexVitreous substructures
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.