Evidence map›Paper›PMID 29940328›Full record

ArticleNeuroscience letters2018

Overexpression of neuronal RNA-binding protein HuD increases reward induced reinstatement of an instrumental response.

Robert J Oliver, Johnny A Kenton, Wennonah Stevens, Nora I Perrone-Bizzozero, Jonathan L Brigman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert J OliverDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
Johnny A KentonDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
Wennonah StevensDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
Nora I Perrone-BizzozeroDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA.
Jonathan L BrigmanDepartment of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA. Electronic address: jbrigman@salud.unm.edu.

Funding

Alcohol Research Training in NeurosciencesT32AA014127 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jonathan L Brigman · 2003 to 2026
$3.3M
Competing roles of microRNAs and RNA-binding proteins in drug addictionR01DA034097 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI NEISEWANDER, JANET L, PERRONE-BIZZOZERO, NORA IRMA · 2012 to 2016
$2.2M
Corticostriatal networks and NMDAR mediation of habitual and flexible actionK22AA020303 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRIGMAN, JONATHAN L · 2011 to 2013
$486k
Opposing roles of miR-495 and HuD in addiction-related plasticity and behaviorF31DA041214 · NIDA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI OLIVER, ROBERT JOHN · 2016 to 2017
$54k
NIAAA NIH HHS K22 AA020303NIAAA NIH HHS T32 AA014127NIDA NIH HHS F31 DA041214NIDA NIH HHS R01 DA034097
6 · The paper itself

Abstract

The neuronal RNA-binding protein HuD is involved in synaptic plasticity and the molecular mechanisms of learning and memory. Previously, we have shown that HuD is upregulated after both spatial and addiction-associated forms of learning, such as conditioned place preference. However, what role HuD plays in non-drug dependent learning and memory is not fully understood. In order to elucidate the role that HuD plays in non-drug appetitive behavior, we assessed mice over-expressing HuD (HuD

Indexed as

RewardAnimalsConditioning, OperantELAV-Like Protein 4Extinction, PsychologicalGene ExpressionMaleMiceMice, Inbred C57BLMice, TransgenicProsencephalonRNA-Binding ProteinsElavl4 protein, mouseELAV-Like Protein 4RNA-Binding ProteinsHuDPost-transcriptional regulationReward seekingRNA binding protein

Identifiers

PMID29940328
PMCPMC6368978

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.