Evidence map›Paper›PMID 29940156›Full record

ReviewEuropean journal of pharmacology2018

Substrates and potential therapeutics of ventricular arrhythmias in heart failure.

Dongze Zhang, Huiyin Tu, Michael C Wadman, Yu-Long Li

Abstract readReview
In one paragraph

Review in European journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Ventricular arrhythmia in congenital heart diseases with a systemic right ventricle.International journal of cardiology. Congenital heart disease · 2023
    Review
  8. Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  9. Article
  10. Review
  11. A single injection of periostin decreases cardiac voltage-gated NaThe Journal of veterinary medical science · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dongze ZhangDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Huiyin TuDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Michael C WadmanDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yu-Long LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: yulongli@unmc.edu.
University of Nebraska Medical Center · US

Funding

Mechanisms of cardiac sympathetic hyperactivity in chronic heart failureR01HL137832 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Yu-Long Li · 2017 to 2026
$4.1M
Potential therapies to improve ventricular vagal function in type 2 diabetesR01HL144146 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LI, YU-LONG · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL137832NHLBI NIH HHS R01 HL144146
6 · The paper itself

Abstract

Heart failure (HF) is a clinical syndrome characterized by ventricular contractile dysfunction. About 50% of death in patients with HF are due to fetal ventricular arrhythmias including ventricular tachycardia and ventricular fibrillation. Understanding ventricular arrhythmic substrates and discovering effective antiarrhythmic interventions are extremely important for improving the prognosis of patients with HF and reducing its mortality. In this review, we discussed ventricular arrhythmic substrates and current clinical therapeutics for ventricular arrhythmias in HF. Base on the fact that classic antiarrhythmic drugs have the limited efficacy, side effects, and proarrhythmic potentials, we also updated some therapeutic strategies for the development of potential new antiarrhythmic interventions for patients with HF.

Indexed as

Anti-Arrhythmia AgentsHeart Conduction SystemHeart FailureHeart VentriclesHumansMyocytes, CardiacPrognosisTachycardia, VentricularTreatment OutcomeVentricular FibrillationAnti-Arrhythmia AgentsAntiarrhythmic drugsCatheter ablationHeart failureVentricular arrhythmiaVentricular arrhythmic substrate

Identifiers

PMID29940156
PMCPMC6083882
OpenAlexW2810742983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.