Evidence map›Paper›PMID 29939494›Full record

ArticlePhysiological reports2018

Activation of the β-common receptor by erythropoietin impairs acetylcholine-mediated vasodilation in mouse mesenteric arterioles.

Cody R Kilar, YanPeng Diao, Larysa Sautina, Sivakumar Sekharan, Shahar Keinan, Bianca Carpino, Kirk P Conrad, Rajesh Mohandas, Mark S Segal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cody R KilarDivision of Nephrology, Hypertension, and Transplantation, College of Medicine, University of Florida, Gainesville, Florida.
YanPeng DiaoDivision of Nephrology, Hypertension, and Transplantation, College of Medicine, University of Florida, Gainesville, Florida.
Larysa SautinaDivision of Nephrology, Hypertension, and Transplantation, College of Medicine, University of Florida, Gainesville, Florida.
Sivakumar SekharanCloud Pharmaceuticals, Inc. 6 Davis Dr, Research Triangle Park, North Carolina.
Shahar KeinanCloud Pharmaceuticals, Inc. 6 Davis Dr, Research Triangle Park, North Carolina.
Bianca CarpinoDivision of Nephrology, Hypertension, and Transplantation, College of Medicine, University of Florida, Gainesville, Florida.
Kirk P ConradDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida.
Rajesh MohandasDivision of Nephrology, Hypertension, and Transplantation, College of Medicine, University of Florida, Gainesville, Florida.
Mark S SegalDivision of Nephrology, Hypertension, and Transplantation, College of Medicine, University of Florida, Gainesville, Florida.
University of Florida · USCloud Pharmaceuticals (United States) · USFlorida College · US

Funding

PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MARTIN, ANATOLE DANIEL · 2014 to 2018
$10.7M
Vascular Smooth Muscle Lysyl Oxidase Mediated Increase in Vessel Stiffness and its Effect on Rho-Kinase Mechanosensors: A Novel Mechanism of Atherosclerosis in Chronic Kidney Disease?K08HL130945 · NHLBI · UNIVERSITY OF FLORIDA · PI MOHANDAS, RAJESH · 2016 to 2021
$826k
NHLBI NIH HHS K08 HL130945NIGMS NIH HHS P50 GM111152
6 · The paper itself

Abstract

Clinically, erythropoietin (EPO) is known to increase systemic vascular resistance and arterial blood pressure. However, EPO stimulates the production of the potent vasodilator, nitric oxide (NO), in culture endothelial cells. The mechanism by which EPO causes vasoconstriction despite stimulating NO production may be dependent on its ability to activate two receptor complexes, the homodimeric EPO (EPOR

Indexed as

AcetylcholineAnimalsArteriolesCytokine Receptor Common beta SubunitEndothelium, VascularErythropoietinMaleMesenteric ArteriesMice, Inbred C57BLNitroprussideOxidative StressReceptors, ErythropoietinRecombinant ProteinsVasodilationVasodilator AgentsAcetylcholineCytokine Receptor Common beta SubunitErythropoietininnate repair receptorNitroprussideReceptors, ErythropoietinRecombinant ProteinsVasodilator AgentsCD131erythropoietinhypertensionβ-common receptor

Identifiers

PMID29939494
PMCPMC6016622
OpenAlexW2810230849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.