ArticleMolecular biology and evolution2018
Specificity of the DNA Mismatch Repair System (MMR) and Mutagenesis Bias in Bacteria.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The unique role ofmBio · 2026Article
- Evolutionary bioenergetics of sporulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification and validation of biomarkers related to mismatch repair for prognosis prediction in glioma.Frontiers in immunology · 2026Article
- GnT Motifs Can Increase T:A→G:C Mutation Rates Over 1000-fold in Bacteria.Molecular biology and evolution · 2025Article
- Evolutionary dynamics of nascent multicellular lineages.Proceedings. Biological sciences · 2025Article
- The mutational landscape of Bacillus subtilis conditional hypermutators shows how proofreading skews DNA polymerase error rates.Nucleic acids research · 2025Article
- An extreme mutational hotspot in nlpD depends on transcriptional induction of rpoS.PLoS genetics · 2025Article
- The Effect of the Presence and Absence of DNA Repair Genes on the Rate and Pattern of Mutation in Bacteria.Genome biology and evolution · 2024Article
- Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogenMarine life science & technology · 2024Article
- Contribution of the SOS response and the DNA repair systems to norfloxacin induced mutations inMarine life science & technology · 2023Article
- Mutation bias and adaptation in bacteria.Microbiology (Reading, England) · 2023Review
- The divergence of mutation rates and spectra across the Tree of Life.EMBO reports · 2023Review
- De Novo Structural Variations of Escherichia coli Detected by Nanopore Long-Read Sequencing.Genome biology and evolution · 2023Article
- Silver nanoparticles elevate mutagenesis of eukaryotic genomes.G3 (Bethesda, Md.) · 2023Article
- Article
- Genomic Legacies of Ancient Adaptation Illuminate GC-Content Evolution in Bacteria.Microbiology spectrum · 2023Article
- Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress.EMBO reports · 2023Article
- A complex interplay of evolutionary forces continues to shape ancient co-occurring symbiont genomes.iScience · 2022Article
- Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges.Nature communications · 2022Article
- 7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli.Nucleic acids research · 2022Article
Corrections and comments
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4 authors.
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Abstract
The mutation rate of an organism is influenced by the interaction of evolutionary forces such as natural selection and genetic drift. However, the mutation spectrum (i.e., the frequency distribution of different types of mutations) can be heavily influenced by DNA repair. Using mutation-accumulation lines of the extremophile bacterium Deinococcus radiodurans ΔmutS1 and the model soil bacterium Pseudomonas fluorescens wild-type and MMR- (Methyl-dependent Mismatch Repair-deficient) strains, we report the mutational features of these two important bacteria. We find that P. fluorescens has one of the highest MMR repair efficiencies among tested bacteria. We also discover that MMR of D. radiodurans preferentially repairs deletions, contrary to all other bacteria examined. We then, for the first time, quantify genome-wide efficiency and specificity of MMR in repairing different genomic regions and mutation types, by evaluating the P. fluorescens and D. radiodurans mutation data sets, along with previously reported ones of Bacillus subtilis subsp. subtilis, Escherichia coli, Vibrio cholerae, and V. fischeri. MMR in all six bacteria shares two general features: 1) repair efficiency is influenced by the neighboring base composition for both transitions and transversions, not limited to transversions as previously reported; and 2) MMR only recognizes indels <4 bp in length. This study demonstrates the power of mutation accumulation lines in quantifying DNA repair and mutagenesis patterns.
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