ArticleNeuropsychology2018
Cognition in older patients with multiple sclerosis compared to patients with amnestic mild cognitive impairment and healthy older adults.
Article in Neuropsychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Is there a link between multiple sclerosis and Alzheimer disease? A critical note.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.Neuropsychology · 2026Article
- Comorbid diabetes and multiple sclerosis negatively affect cognitive functioning in older adults.Multiple sclerosis and related disorders · 2025Article
- The ageing central nervous system in multiple sclerosis: the imaging perspective.Brain : a journal of neurology · 2024Review
- Comparing Cognitive Profiles in Older Adults With Multiple Sclerosis and Alzheimer Disease: More Similarities Than Differences.Neurology. Clinical practice · 2024Article
- Advanced neuroimaging techniques to explore the effects of motor and cognitive rehabilitation in multiple sclerosis.Journal of neurology · 2024Review
- The brief repeatable battery of neuropsychological tests (BRB-N) version a: update of Italian normative data from the Italian Neuroimaging Network Initiative (INNI).Journal of neurology · 2024Article
- Cortical thickness and cognition in older people with multiple sclerosis.Journal of neurology · 2023Article
- Impact of aging on treatment considerations for multiple sclerosis patients.Frontiers in neurology · 2023Review
- Cognitive Decline in Older People with Multiple Sclerosis-A Narrative Review of the Literature.Geriatrics (Basel, Switzerland) · 2022Review
- Cognitive Profiles of Aging in Multiple Sclerosis.Frontiers in aging neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveProgress in the treatment of multiple sclerosis (MS) has resulted in larger numbers of patients living to an advanced age, but little is known about the cognitive status of these individuals. The primary purpose of this study was to identify differences in the cognitive performance between elderly individuals with MS and those with amnestic mild cognitive impairment (aMCI).
methodThree groups ranging in age from 60 to 80 were compared: patients with MS (n = 64), patients with aMCI (n = 58), and healthy adults (n = 70). All participants completed a standard neuropsychological test battery that evaluated domains of attention, processing speed, executive function, memory, language, and visual spatial function.
resultsCompared to age- and gender-matched healthy controls, elderly MS patients exhibited a pattern of cognitive impairment centering on information processing speed and memory that was consistent with the deficits observed in other studies of MS patients regardless of age. Compared to aMCI patients, the MS patients exhibited worse performance on measures of processing speed, but better performance on a measure of memory under cued conditions (Selective Reminding Test), a nonspeeded measure of language (Boston Naming Test), and measures of executive function with processing speed statistically controlled (Trail Making Test, Stroop Test).
conclusionsDifferences on neuropsychological measures can serve to distinguish aMCI from MS-related cognitive impairment in older patients, but it is essential that these measures control for the deficit in processing speed that is such a primary feature of MS. (PsycINFO Database Record
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