Evidence map›Paper›PMID 29938598›Full record

ArticleAutophagy2018

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.

Bing Han, Yuan Zhang, Yanhong Zhang, Ying Bai, Xufeng Chen, Rongrong Huang, Fangfang Wu, Shuo Leng, Jie Chao, John H Zhang and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 5 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 5 syntheses or guidelines pooled it, 354 citations in OpenAlex.

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  12. METTL16 Promotes Cerebral Ischemia-Reperfusion Injury via mInternational journal of general medicine · 2026
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152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Bing Hana Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Yuan Zhanga Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Yanhong Zhanga Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Ying Baia Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Xufeng Chenb Department of Emergency , Jiangsu Province Hospital and The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu , China.
Rongrong Huanga Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Fangfang Wua Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Shuo Lengc Department of Radiology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Jie Chaod Department of Physiology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
John H Zhange Department of Physiology and Pharmacology , School of Medicine, Loma Linda University , Loma Linda , California , USA.
Gang Huf Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology , Nanjing Medical University , Nanjing , Jiangsu , China.
Honghong Yaoa Department of Pharmacology , School of Medicine, Southeast University , Nanjing , Jiangsu , China.
Southeast University · CNNanjing Medical University · CNLoma Linda University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are highly expressed in the central nervous system and are involved in the regulation of physiological and pathophysiological processes. However, the potential role of circRNAs in stroke remains largely unknown. Here, using a circRNA microarray, we showed that circular RNA Hectd1 (circHectd1) levels were significantly increased in ischemic brain tissues in transient middle cerebral artery occlusion (tMCAO) mouse stroke models and further validated this finding in plasma samples from acute ischemic stroke (AIS) patients. Knockdown of circHectd1 expression significantly decreased infarct areas, attenuated neuronal deficits, and ameliorated astrocyte activation in tMCAO mice. Mechanistically, circHECTD1 functions as an endogenous MIR142 (microRNA 142) sponge to inhibit MIR142 activity, resulting in the inhibition of TIPARP (TCDD inducible poly[ADP-ribose] polymerase) expression with subsequent inhibition of astrocyte activation via macroautophagy/autophagy. Taken together, the results of our study indicate that circHECTD1 and its coupling mechanism are involved in cerebral ischemia, thus providing translational evidence that circHECTD1 can serve as a novel biomarker of and therapeutic target for stroke. ABBREVIATIONS: 3-MA: 3-methyladenine; ACTB: actin beta; AIS: acute ischemic stroke; AS: primary mouse astrocytes; BECN1: beclin 1, autophagy related; BMI: body mass index; circHECTD1: circRNA HECTD1; circRNAs: circular RNAs; CBF: cerebral blood flow; Con: control; DAPI: 4',6-diamidino-2-phenylindole; ECA: external carotid artery; FISH: fluorescence in situ hybridization; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; Gdna: genomic DNA; GFAP: glial fibrillary acidic protein; GO: gene ontology; HDL: high-density lipoprotein; IOD: integrated optical density; LDL: low-density lipoprotein; LPA: lipoprotein(a); MAP1LC3B: microtubule-associated protein 1 light chain 3 beta; MIR142: microRNA 142; mNSS: modified neurological severity scores; MRI: magnetic resonance imaging; NIHSS: National Institute of Health Stoke Scale; OGD-R: oxygen glucose deprivation-reperfusion; PCR: polymerase chain reaction; PFA: paraformaldehyde; SQSTM1: sequestosome 1; TIPARP: TCDD inducible poly(ADP-ribose) polymerase; tMCAO: transient middle cerebral artery occlusion; TTC: 2,3,5-triphenyltetrazolium chloride; UTR: untranslated region; WT: wild type.

Indexed as

AutophagyAgedAnimalsAstrocytesBase SequenceBrain InfarctionBrain IschemiaFemaleHumansInfarction, Middle Cerebral ArteryMaleMice, Inbred C57BLMicroRNAsNucleoside Transport ProteinsPoly(ADP-ribose) PolymerasesRNA2,3,7,8-tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase, mouseMicroRNAsMIRN142 microRNA, humanMirn142 microRNA, mouseNucleoside Transport ProteinsPoly(ADP-ribose) PolymerasesRNARNA, CircularTiPARP protein, humanAstrocyte activationautophagycircHECTD1MIR142strokeTIPARPtMCAO

Identifiers

PMID29938598
PMCPMC6103660
OpenAlexW2810401400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.