Evidence map›Paper›PMID 29938387›Full record

ArticleJournal of anesthesia2018

Myotoxicity of local anesthetics is equivalent in individuals with and without predisposition to malignant hyperthermia.

Sachiko Otsuki, Toshimichi Yasuda, Keiko Mukaida, Yuko Noda, Rieko Kanzaki, Hirotsugu Miyoshi, Takashi Kondo, Hiroshi Hamada, Masashi Kawamoto

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of anesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Effects of Remimazolam and Propofol on CaBioMed research international · 2021
    Article
  6. Article
  7. Review
  8. Non-traumatic and non-drug-induced rhabdomyolysis.Archives of medical sciences. Atherosclerotic diseases · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sachiko OtsukiDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. sachi85@hiroshima-u.ac.jp.ORCID 0000-0003-4771-9867
Toshimichi YasudaDepartment of Anesthesiology and Critical Care, Graduate School of Biomedical Sciences, Hirohima University, Hiroshima, Japan.
Keiko MukaidaDepartment of Anesthesiology, Hiroshima Prefectural Rehabilitation Center, Higashi-hiroshima, Japan.
Yuko NodaDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Rieko KanzakiDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hirotsugu MiyoshiDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Takashi KondoDepartment of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hiroshi HamadaDepartment of Anesthesiology and Critical Care, Graduate School of Biomedical Sciences, Hirohima University, Hiroshima, Japan.
Masashi KawamotoDepartment of Anesthesiology and Critical Care, Graduate School of Biomedical Sciences, Hirohima University, Hiroshima, Japan.
Hiroshima University Hospital · JPHiroshima Prefectural Rehabilitation Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMalignant hyperthermia (MH) is an inherited muscle disorder caused by abnormal elevations of intracellular calcium (Ca

methodsHuman skeletal muscle samples were obtained from 22 individuals to determine susceptibility to MH, and were evaluated according to whether their Ca

resultsIn the accelerated and unaccelerated groups, respectively, the mean ± SD of the EC

conclusionThe myotoxicity of local anesthetics was equivalent in individuals with and without predisposition to MH.

Indexed as

AdolescentAdultAnesthetics, LocalCalciumChildFemaleHumansLevobupivacaineLidocaineMaleMalignant HyperthermiaMiddle AgedMuscle, SkeletalRopivacaineAnesthetics, LocalCalciumLevobupivacaineLidocaineRopivacaineLocal anestheticsMalignant hyperthermiaMyotoxicity

Identifiers

PMID29938387
OpenAlexW2810240989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.