Evidence map›Paper›PMID 29938353›Full record

ArticleVeterinary research communications2018

Doxycycline treatment for Dirofilaria immitis in dogs: impact on Staphylococcus aureus and Enterococcus antimicrobial resistance.

María Teresa Tejedor-Junco, Margarita González-Martín, Estefanía Bermeo-Garrido, Rebeca Villasana-Loaiza, Elena Carretón-Gómez

Abstract read
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In one paragraph

Article in Veterinary research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

María Teresa Tejedor-JuncoResearch Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35016, Las Palmas de Gran Canaria, Canary Islands, Spain. mariateresa.tejedor@ulpgc.es.ORCID http://orcid.org/0000-0003-2387-1426
Margarita González-MartínResearch Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35016, Las Palmas de Gran Canaria, Canary Islands, Spain.
Estefanía Bermeo-GarridoMicrobiology, Faculty of Veterinary, University of Las Palmas de Gran Canaria, P.O. BOX 550, 35080, Las Palmas de Gran Canaria, Canary Islands, Spain.
Rebeca Villasana-LoaizaMicrobiology, Faculty of Veterinary, University of Las Palmas de Gran Canaria, P.O. BOX 550, 35080, Las Palmas de Gran Canaria, Canary Islands, Spain.
Elena Carretón-GómezResearch Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35016, Las Palmas de Gran Canaria, Canary Islands, Spain.
Universidad de Las Palmas de Gran Canaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Doxycycline is an antibiotic that, in addition to the classic antibacterial use, is also prescribed to fight parasitic diseases, like heartworm disease in dogs. Despite the concern that the overuse of this antibiotic may decrease susceptibility of clinically important bacteria, the consequences of the prolonged doxycycline therapy in heartworm-infected dogs have never been studied before. We have analyzed the impact of this therapy on Staphylococcus aureus and Enterococcus antimicrobial resistance. In this study, 17 heartworm-infected dogs (10 that had completed the doxycycline treatment and 7 dogs that had not yet begun) were included. Twenty-four isolates of Staphylococcus aureus were obtained from two locations of each dog. After treatment, 73.3% of isolates were resistant to at least one antibiotic but only 22.2% of isolates before treatment. Most of doxycycline resistant isolates were obtained from dogs that have received treatment. Erythromycin resistance or intermediate susceptibility was detected in 45.6% of isolates, most of them from dogs after treatment. For Enterococci, 48 isolates were obtained from fecal samples (25 before treatment and 23 after treatment). Before treatment, 32% of isolates were resistant at least to one antibiotic while after, this data increase up to 65%. Comparing isolates before and after treatment, a clear increase in resistance to doxycycline (12% against 21.74%) and erythromycin (20% against 39.13%) was observed. Although the present work is a preliminary research, the results encourages the development of further studies to determinate the effect of prolonged doxycycline therapy on antimicrobial resistance.

Indexed as

Drug Resistance, BacterialAnimalsDirofilaria immitisDirofilariasisDog DiseasesDogsDoxycyclineEnterococcusFilaricidesStaphylococcus aureusVirulence FactorsDoxycyclineFilaricidesVirulence FactorsAntimicrobial resistanceDirofilariaDoxycyclineEnterococcusStaphylococcus

Identifiers

PMID29938353
OpenAlexW2810688140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.