Evidence map›Paper›PMID 29938249›Full record

ArticleJCO precision oncology2017

Duodenal-Jejunal Flexure GI Stromal Tumor Frequently Heralds Somatic

Adam M Burgoyne, Martina De Siena, Maha Alkhuziem, Chih-Min Tang, Benjamin Medina, Paul T Fanta, Martin G Belinsky, Margaret von Mehren, John A Thorson, Lisa Madlensky and 6 more

Open access · greenAbstract read
In one paragraph

Article in JCO precision oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.Journal of the National Comprehensive Cancer Network : JNCCN · 2022
    Article
  8. Review
  9. Review
  10. Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Article
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Adam M BurgoyneUniversity of California, San Diego, La Jolla, CA.
Martina De SienaUniversity of California, San Diego, La Jolla, CA; Sapienza e Università di Roma, Rome, Italy.
Maha AlkhuziemUniversity of California, San Diego, La Jolla, CA.
Chih-Min TangUniversity of California, San Diego, La Jolla, CA.
Benjamin MedinaMemorial Sloan Kettering Cancer Center, New York, NY.
Paul T FantaUniversity of California, San Diego, La Jolla, CA.
Martin G BelinskyFox Chase Cancer Center, Philadelphia, PA.
Margaret von MehrenFox Chase Cancer Center, Philadelphia, PA.
John A ThorsonUniversity of California, San Diego, La Jolla, CA.
Lisa MadlenskyUniversity of California, San Diego, La Jolla, CA.
Timothy BowlerMemorial Sloan Kettering Cancer Center, New York, NY.
Francesco D'AngeloSapienza e Università di Roma, Rome, Italy.
Dwayne G StupackUniversity of California, San Diego, La Jolla, CA.
Olivier HarismendyUniversity of California, San Diego, La Jolla, CA.
Ronald P DeMatteoMemorial Sloan Kettering Cancer Center, New York, NY.
Jason K SicklickUniversity of California, San Diego, La Jolla, CA.
University of Siena · IT

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
iDASH: Integrating Data for Analysis, Anonymization, and SharingU54HL108460 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2015
$19.1M
Molecular Mechanisms in Gastrointestinal Stromal TumorR01CA102613 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2004 to 2026
$9.2M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7M
Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
In vivo detection and genome-wide location analysis of DNA-adductsR21CA177519 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HARISMENDY, OLIVIER, HOWELL, STEPHEN B · 2013 to 2015
$667k
Defining the Germline Genomic Landscape of a Novel GIST Multi-tumor SyndromeR21CA192072 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2016 to 2017
$399k
NCI NIH HHS K08 CA168999NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA102613NCI NIH HHS R21 CA177519NCI NIH HHS R21 CA192072NCI NIH HHS T32 CA009501NHLBI NIH HHS U54 HL108460
6 · The paper itself

Abstract

purposeGI stromal tumors (GISTs) are commonly associated with somatic mutations in

methodsWe describe the demographic/clinicopathologic features of 177 patients from two institutions whose GISTs underwent next-generation sequencing of ≥315 cancer-related genes.

resultsWe initially identified six (9.7%) of 62 GISTs with

conclusionBroad genomic profiling of adult GISTs has revealed that

Identifiers

PMID29938249
PMCPMC6013064
OpenAlexW2748782166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.