Evidence map›Paper›PMID 29938202›Full record

ArticleFrontiers in cellular and infection microbiology2018

Lipid A Has Significance for Optimal Growth of

Tao Wang, Yonghui Yu, Xiaofei Liang, Shengdong Luo, Zemin He, Zhihui Sun, Yongqiang Jiang, Anders Omsland, Pei Zhou, Lihua Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Review
  3. TheJournal of bacteriology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tao WangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yonghui YuState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Xiaofei LiangDepartment of Chemistry, Duke University, Durham, NC, United States.
Shengdong LuoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zemin HeState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhihui SunState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yongqiang JiangState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Anders OmslandPaul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Pei ZhouDepartment of Biochemistry, Duke University Medical Center, Durham, NC, United States.
Lihua SongState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Institute of Microbiology · CNDuke Medical Center · USDuke University · USWashington State University · US

Funding

Biochemistry and Structure of Lipid A EnzymesR01GM115355 · NIGMS · DUKE UNIVERSITY · PI ZHOU, PEI · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM115355
6 · The paper itself

Abstract

Lipid A is an essential basal component of lipopolysaccharide of most Gram-negative bacteria. Inhibitors targeting LpxC, a conserved enzyme in lipid A biosynthesis, are antibiotic candidates against Gram-negative pathogens. Here we report the characterization of the role of lipid A in

Indexed as

AmidohydrolasesAnimalsAxenic CultureBacterial ProteinsChlorocebus aethiopsCoxiella burnetiiEscherichia coliHumansHydroxamic AcidsLipid AMacrophagesTHP-1 CellsThreonineVacuolesVero CellsAmidohydrolasesBacterial ProteinsHydroxamic AcidsLipid ALPC-011ThreonineUDP-3-O-acyl-N-acetylglucosamine deacetylaseCoxiella burnetiilipid ALPC-011LPSLpxC inhibitorQ fever

Identifiers

PMID29938202
PMCPMC6002510
OpenAlexW2804026402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.