ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018
Microstructured Elastomer-PEG Hydrogels via Kinetic Capture of Aqueous Liquid-Liquid Phase Separation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- FABRICATION OF PATTERNED HYDROGELS WITH CONTROLLED MECHANICAL PROPERTIES USING CHEMICALLY MODIFIED RLPS.International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and Exposition · 2026Article
- Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Programmability and biomedical utility of intrinsically-disordered protein polymers.Advanced drug delivery reviews · 2024Review
- Determinants that enable disordered protein assembly into discrete condensed phases.Nature chemistry · 2024Article
- Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Review
- Connective tissue inspired elastomer-based hydrogel for artificial skin via radiation-indued penetrating polymerization.Nature communications · 2024Article
- Sequence-Encoded Differences in Phase Separation Enable Formation of Resilin-like Polypeptide-Based Microstructured Hydrogels.Biomacromolecules · 2023Article
- Lipid-driven condensation and interfacial ordering of FUS.Science advances · 2022Article
- Biophysical studies of phase separation integrating experimental and computational methods.Current opinion in structural biology · 2021Review
- Application of Thermoresponsive Intrinsically Disordered Protein Polymers in Nanostructured and Microstructured Materials.Macromolecular bioscience · 2021Review
- Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Resilin-mimetics as a smart biomaterial platform for biomedical applications.Nature communications · 2021Review
- Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
- Molecular Details of Protein Condensates Probed by Microsecond Long Atomistic Simulations.The journal of physical chemistry. B · 2020Article
- Anisotropic, porous hydrogels templated by lyotropic chromonic liquid crystals.Journal of materials chemistry. B · 2020Article
- Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties.Annual review of physical chemistry · 2020Review
- Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties.Biomaterials science · 2020Article
- Biocompatibility and Viscoelastic Properties of Injectable Resilin-Like Polypeptide and Hyaluronan Hybrid Hydrogels in Rabbit Vocal Folds.Regenerative engineering and translational medicine · 2019Article
- Hybrid hydrogels for biomedical applications.Current opinion in chemical engineering · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Heterogeneous hydrogels with desired matrix complexity are studied for a variety of biomimetic materials. Despite the range of such microstructured materials described, few methods permit independent control over microstructure and microscale mechanics by precisely controlled, single-step processing methods. Here, a phototriggered crosslinking methodology that traps microstructures in liquid-liquid phase-separated solutions of a highly elastomeric resilin-like polypeptide (RLP) and poly(ethylene glycol) (PEG) is reported. RLP-rich domains of various diameters can be trapped in a PEG continuous phase, with the kinetics of domain maturation dependent on the degree of acrylation. The chemical composition of both hydrogel phases over time is assessed via in situ hyperspectral coherent Raman microscopy, with equilibrium concentrations consistent with the compositions derived from NMR-measured coexistence curves. Atomic force microscopy reveals that the local mechanical properties of the two phases evolve over time, even as the bulk modulus of the material remains constant, showing that the strategy permits control of mechanical properties on micrometer length scales, of relevance in generating mechanically robust materials for a range of applications. As one example, the successful encapsulation, localization, and survival of primary cells are demonstrated and suggest the potential application of phase-separated RLP-PEG hydrogels in regenerative medicine applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.