Evidence map›Paper›PMID 29938138›Full record

ArticlePeerJ2018

Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models.

Bingyu Ye, Wenlong Shen, Minglei Shi, Yan Zhang, Cunshuan Xu, Zhihu Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Int&in: A machine learning-based web server for active split site identification in inteins.Protein science : a publication of the Protein Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bingyu YeCollege of Life Science, Henan Normal University, Xinxiang, China.ORCID 0000-0001-9376-2861
Wenlong ShenBeijing Institute of Biotechnology, Beijing, China.ORCID 0000-0002-2293-5590
Minglei ShiBeijing Institute of Biotechnology, Beijing, China.ORCID 0000-0002-1108-4233
Yan ZhangBeijing Institute of Biotechnology, Beijing, China.
Cunshuan XuCollege of Life Science, Henan Normal University, Xinxiang, China.
Zhihu ZhaoBeijing Institute of Biotechnology, Beijing, China.ORCID 0000-0001-7081-8914
Henan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEntolimod is a

methodsWe designed and constructed cyclic entolimod using split

resultsThe circular entolimod showed significantly increased both the in vitro NF-κB signaling and in vivo radioprotective activity in mice.

conclusionOur data indicates that circular entolimod might be a good candidate for further clinical investigation.

Indexed as

CyclizationEntolimodNpu DnaE inteinRadioprotective activity

Identifiers

PMID29938138
PMCPMC6011820
OpenAlexW2795087974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.