Evidence map›Paper›PMID 29938020›Full record

ArticleChemical science2018

A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes.

Theresa M Welle, Kristen Alanis, Michelle L Colombo, Jonathan V Sweedler, Mei Shen

Abstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid-β Plaques.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Chemical science · 2022
    Article
  11. Article
  12. Nanoelectrochemistry in the study of single-cell signaling.Analytical and bioanalytical chemistry · 2020
    Review
  13. Review
  14. Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Theresa M WelleDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Matthews Avenue , Urbana , IL 61801 , USA . Email: mshen233@illinois.edu ; Tel: +1-217-265-6290.ORCID 0000-0001-6138-240X
Kristen AlanisDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Matthews Avenue , Urbana , IL 61801 , USA . Email: mshen233@illinois.edu ; Tel: +1-217-265-6290.ORCID 0000-0001-9044-0752
Michelle L ColomboDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Matthews Avenue , Urbana , IL 61801 , USA . Email: mshen233@illinois.edu ; Tel: +1-217-265-6290.ORCID 0000-0003-2063-6615
Jonathan V SweedlerDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Matthews Avenue , Urbana , IL 61801 , USA . Email: mshen233@illinois.edu ; Tel: +1-217-265-6290.ORCID 0000-0003-3107-9922
Mei ShenDepartment of Chemistry , University of Illinois at Urbana-Champaign , 600 South Matthews Avenue , Urbana , IL 61801 , USA . Email: mshen233@illinois.edu ; Tel: +1-217-265-6290.ORCID 0000-0002-6033-8308

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
Structural Elucidation and Biosynthesis P01GM077596 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2007 to 2016
$15.3M
The National Resource for Aplysia-Curation & Informatics.P40OD010952 · OD · UNIVERSITY OF MIAMI ROSENTEIL SCHOOL · PI M Danielle McDonald · 2012 to 2026
$10.7M
A Scalable Platform to Discover Antimicrobials of Ribosomal OriginR01AI144967 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Douglas Alan Mitchell, WILFRED A. VAN DER DONK · 2019 to 2026
$6.0M
Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Posttranslational Modifications in Natural Product BiosynthesisR01GM058822 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 1999 to 2015
$3.8M
Study Exocytosis in the Region of Synaptic Cleft using Electrochemical NanoprobeR21NS085665 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SHEN, MEI · 2013 to 2014
$391k
NIDA NIH HHS P30 DA018310NIGMS NIH HHS P01 GM077596NIGMS NIH HHS R01 GM058822NIGMS NIH HHS T32 GM070421NIH HHS P40 OD010952NINDS NIH HHS R21 NS085665
6 · The paper itself

Abstract

Extra-synaptic exocytosis is an essential component of cellular communication. A knowledge gap exists in the exocytosis of the non-redox active transmitter acetylcholine. Using the nano-interface between two immiscible electrolyte solutions and scanning electrochemical microscopy (SECM), a high resolution spatiotemporal study of acetylcholine exocytosis is shown from an individual neuronal soma. The nanoelectrode was positioned ∼140 nm away from the release sites on the soma using an SECM. The quantitative study enables the obtaining of key information related to cellular communication, including extracellular concentration of the neurotransmitter, cellular permeability, Ca

Identifiers

PMID29938020
PMCPMC5994989

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.