Evidence map›Paper›PMID 29937934›Full record

ArticleJournal of Cancer2018

MicroRNA-30b targets Snail to impede epithelial-mesenchymal transition in pancreatic cancer stem cells.

Yicheng Xiong, Yao Wang, Lei Wang, Yan Huang, Yang Xu, Liancheng Xu, Yibing Guo, Jingjing Lu, Xiaohong Li, Mingyan Zhu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. MicroRNA-495: a therapeutic and diagnostic tumor marker.Journal of molecular histology · 2023
    Review
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yicheng XiongGeneral Surgery Department, the First Affiliated Hospital of Soochow University, 215006, Suzhou, Jiangsu, P.R. China.
Yao WangGeneral Surgery Department, Affiliated Hospital of Nantong University,226001, Nantong, Jiangsu, P.R. China.
Lei WangGeneral Surgery Department, Affiliated Hospital of Nantong University,226001, Nantong, Jiangsu, P.R. China.
Yan HuangGeneral Surgery Department, Affiliated Hospital of Nantong University,226001, Nantong, Jiangsu, P.R. China.
Yang XuGeneral Surgery Department, Affiliated Hospital of Nantong University,226001, Nantong, Jiangsu, P.R. China.
Liancheng XuGeneral Surgery Department, Affiliated Hospital of Nantong University,226001, Nantong, Jiangsu, P.R. China.
Yibing GuoClinical Medical Research Center, Affiliated Hospital of Nantong University, 226001, Nantong, Jiangsu, P.R. China.
Jingjing LuClinical Medical Research Center, Affiliated Hospital of Nantong University, 226001, Nantong, Jiangsu, P.R. China.
Xiaohong LiClinical Medical Research Center, Affiliated Hospital of Nantong University, 226001, Nantong, Jiangsu, P.R. China.
Mingyan ZhuGeneral Surgery Department, Affiliated Hospital of Nantong University,226001, Nantong, Jiangsu, P.R. China.
Haixin QianGeneral Surgery Department, the First Affiliated Hospital of Soochow University, 215006, Suzhou, Jiangsu, P.R. China.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CNNantong University · CNAffiliated Hospital of Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Snail-mediated epithelial-mesenchymal transition (EMT) process plays a fundamental role in facilitating pancreatic ductal adenocarcinoma (PDAC) stemness and metastasis. In the present study, we revealed that microRNA-30 (miR-30) members, especially miR-30b, were remarkably downregulated in triple-positive (CD24

Indexed as

epithelial-mesenchymal transitionmiR-30bpancreatic cancer stem cellspancreatic ductal adenocarcinomaSnail

Identifiers

PMID29937934
PMCPMC6010678
OpenAlexW2805282558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.