ArticleAfrican health sciences2017
Neurocalcin-delta: a potential memory-related factor in hippocampus of obese rats induced by high-fat diet.
Article in African health sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.Molecular neurodegeneration · 2023Pooled it
- Identification and Pathway Analysis of SNP Loci Affecting Abdominal Fat Deposition in Broilers.Animals : an open access journal from MDPI · 2025Article
- Genome-Wide Association Study of Egg-Laying Traits and Egg Quality in LingKun Chickens.Frontiers in veterinary science · 2022Article
- Gene Expression Profiling in the Striatum ofBiomolecules & therapeutics · 2021Article
- Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity.Behavioural brain research · 2020Article
- Low expression of NCALD is associated with chemotherapy resistance and poor prognosis in epithelial ovarian cancer.Journal of ovarian research · 2020Article
- A systematic review on different models of inducing obesity in animals: Advantages and limitations.Journal of advanced veterinary and animal research · 2020Review
- High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia.Journal of translational medicine · 2019Article
- HIV and NCDs: inevitable interaction in resource limited settings.African health sciences · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionAberrant protein expression within the hippocampus has recently been implicated in the pathogenesis of obesity-induced memory impairment.
objectivesThe objective of the current study was to search for specific memory-related factors in the hippocampus in obese rats.
methodsSprague-Dawley (SD) rats were fed either a high-fat (HF) diet or normal-fat (NF) diet for 10 weeks to obtain the control (CON), diet-induced obese rats (DIO) and diet-resistant (DR) rats. D-galactose was injected subcutaneously for 10 weeks to establish model (MOD) rats with learning and memory impairment. After the hippocampus of the rats sampling, the proteome analysis was conducted using two-dimensional get electrophoresis (2-DE) combined with peptide mass fingerprinting (PMF).
resultsWe found 15 differential proteins that expressed in the hippocampus in rats induced by HF diet from the 2-DE map. In addition, Neurocalcin-delta (NCALD) was nearly down-regulated in the DR rats compared with CON rats and MOD rats, which was further confirmed by Western blot, real-time PCR and ELISA results.
conclusionOur data demonstrates that the differential memory-related proteins were a reflection of the HF diet, but not potential factors in obesity proneness or obesity resistance. Furthermore, NCALD is proved to be a potential hippocampus-memory related factor related to obesity.
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