ArticleAfrican health sciences2017
Idiopathic nephrotic syndrome in South African children.
Article in African health sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Hiding in plain sight: genetics of childhood steroid-resistant nephrotic syndrome in Sub-Saharan Africa.Pediatric nephrology (Berlin, Germany) · 2023Review
- Trends in the epidemiology of childhood nephrotic syndrome in Africa: A systematic review.Global epidemiology · 2021Review
- Treatment Outcomes of Pediatric Nephrotic Syndrome Patients Treated in Ayder Comprehensive Specialized and Mekelle General Hospitals, Ethiopia.International journal of nephrology and renovascular disease · 2021Article
- Changing epidemiology of nephrotic syndrome in Nigerian children: A cross-sectional study.PloS one · 2020Article
- Nephrotic Syndrome in South African Children: Changing Perspectives in the New Millennium.Kidney international reports · 2019Review
- HIV and NCDs: inevitable interaction in resource limited settings.African health sciences · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location.
objectiveTo provide an update on the steroid response and renal histo-pathological pattern in children treated for INS.
methodMedical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed.
resultsMean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2-6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%).
conclusionThere appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.