Evidence map›Paper›PMID 29937865›Full record

ArticleAfrican health sciences2017

The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis.

Sophie Nalukwago, Christina L Lancioni, Joy Baseke Oketcho, Dave H E Canaday, W Henry Boom, Lonzy Ojok, Harriet Mayanja-Kizza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sophie NalukwagoJoint Clinical Research Centre, Kampala, Uganda.
Christina L LancioniDepartment of Paediatric infectious diseases, Oregon Health Sciences University, Portland Oregon.
Joy Baseke OketchoJoint Clinical Research Centre, Kampala, Uganda.
Dave H E CanadayDivision of Infectious Diseases, Case Western Reserve University.
W Henry BoomDivision of Infectious Diseases, Case Western Reserve University.
Lonzy OjokDepartment of pathology, Makerere University College of Veterinary Medicine, Animal resources and biosecurity, Kampala, Uganda.
Harriet Mayanja-KizzaSchool of Medicine, Makerere University College of Health Sciences, Mulago Hospital, Kampala, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe reconstitution of cellular immune components contributes to clinical outcome of HIV and

objectivesTo ascertain the effect of interrupted ART on reconstitution of CD4

methodsParticipants with HIV (CD4>350 cells/µL) and TB were recruited under a larger phase 3 open label randomised controlled clinical trial. The CD45RO and CD62L markers were measured on CD4

resultsThere was a significant increase of naive CD8

conclusionInterrupting ART alters CD8

Indexed as

AdultAnti-Retroviral AgentsAntitubercular AgentsCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleFlow CytometryHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeImmunologic MemoryMaleMycobacterium tuberculosisTuberculosis, PulmonaryViral LoadAnti-Retroviral AgentsAntitubercular Agentsactive pulmonary tuberculosisHIV patientsInterrupted anti-retroviral treatmentmemory and naive T cells

Identifiers

PMID29937865
PMCPMC5870287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.