ArticleJournal of otology2016
Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy.
Article in Journal of otology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Rigid Autofluorescence Imaging as a Tool for Identifying Cholesteatoma During Otologic Surgery: Initial Ex Vivo Findings.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024Review
- Inner ear barriers to nanomedicine-augmented drug delivery and imaging.Journal of otology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy (CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining. MATERIALS AND
methodsSpecimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy, two-photon excited fluorescence (TPEF) microscopy, and the second harmonic generation (SHG) microscopy.
resultsIn cholesteatoma tissues from the mastoid, a strong resonant signal at 2845 cm
conclusionThese results suggest the need to develop a novel CARS microendoscope that can be used in combination with TPEF/SHG to distinguish cholesteatoma from inflammatory tissues.
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