ReviewFrontiers in systems neuroscience2018
The Role of the Lateral Hypothalamus in Violent Intraspecific Aggression-The Glucocorticoid Deficit Hypothesis.
Review in Frontiers in systems neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Lateral hypothalamus to dorsal raphe nucleus projections modulate intraspecific attack behavior in male mice.iScience · 2026Article
- Repeated Stress Escalates Aggression and Activity in Fronto-Limbic Regions in Cntnap2Genes, brain, and behavior · 2026Article
- Prolonged Aggressive Experience Accelerates Resolution of Inflammation in Blood and Microglia After Repeated LPS Treatment.International journal of molecular sciences · 2025Article
- Inhibition of the lateral hypothalamus emboldens adult female spiny mice to huddle with an established group of novel peers.Scientific reports · 2025Article
- Article
- Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults.Journal of psychiatric research · 2025Article
- Functional cerebello-cortico-limbic connectivity in aggression: A resting-state 7T fMRI study in healthy volunteers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Hypothalamic connectivities and self-evaluated aggression in young adults.bioRxiv : the preprint server for biology · 2024Article
- Tickle fetishism: pleasure beyond playfulness.Frontiers in psychology · 2024Article
- Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling: relevance to aggressive behavior in humans.Discover mental health · 2023Article
- Hypothalamic volume in pedophilia with or without child sexual offense.European archives of psychiatry and clinical neuroscience · 2023Article
- Aggression, Aggression-Related Psychopathologies and Their Models.Frontiers in behavioral neuroscience · 2022Review
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
This review argues for a central role of the lateral hypothalamus in those deviant forms of aggression, which result from chronic glucocorticoid deficiency. Currently, this nucleus is considered a key region of the mechanisms that control predatory aggression. However, recent findings demonstrate that it is strongly activated by aggression in subjects with a chronically downregulated hypothalamus-pituitary-adrenocortical (HPA) axis; moreover, this activation is causally involved in the emergence of violent aggression. The review has two parts. In the first part, we review human findings demonstrating that under certain conditions, strong stressors downregulate the HPA-axis on the long run, and that the resulting glucocorticoid deficiency is associated with violent aggression including aggressive delinquency and aggression-related psychopathologies. The second part addresses neural mechanisms in animals. We show that the experimental downregulation of HPA-axis function elicits violent aggression in rodents, and the activation of the brain circuitry that originally subserves predatory aggression accompanies this change. The lateral hypothalamus is not only an integral part of this circuitry, but can elicit deviant and violent forms of aggression. Finally, we formulate a hypothesis on the pathway that connects unfavorable social conditions to violent aggression via the neural circuitry that includes the lateral hypothalamus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.