ArticleJournal of geriatric oncology2019
Functional trajectories before and after a new cancer diagnosis among community-dwelling older adults.
Article in Journal of geriatric oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of rehabilitation and exercise recommendations in oncology guidelines.CA: a cancer journal for clinicians · 2021Pooled it
- Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer.Journal of geriatric oncology · 2024Trial
- Expanding the lexicon: integrating medical rehabilitation and prehabilitation into "supportive care".Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Physical Function and Residential Relocation of Older Adults Living With Chronic Conditions.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- An exploratory analysis of 24-h movement behaviors in individuals with cancer completing a 12-week resistance exercise intervention.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Multidimensional functional limitations in American cancer survivors: Characteristics and their effects on survival and healthcare utilization.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- A scoping review evaluating physical and cognitive functional outcomes in cancer survivors treated with chemotherapy: charting progress since the 2018 NCI think tank on cancer and aging phenotypes.Journal of cancer survivorship : research and practice · 2024Article
- Assessment of Mobility Trajectories Using Wearable Inertial Sensors During Autologous Hematopoietic Cell Transplant.Archives of physical medicine and rehabilitation · 2024Article
- Article
- Risk Factors for Immune Checkpoint Inhibitor Immunotherapy Toxicity Among Older Adults with Cancer.The oncologist · 2023Article
- Change in four measures of physical function among older adults during lung cancer treatment: A mixed methods cohort study.Journal of geriatric oncology · 2023Article
- Feasibility of an embedded palliative care clinic model for patients with an advanced thoracic malignancy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Observational
- Functional Trajectories and Resilience Among Adults With Advanced Lung Cancer.JTO clinical and research reports · 2022Article
- Functional limitations before and after cancer diagnosis and contributing factors: findings from the China health and retirement longitudinal study.BMC geriatrics · 2022Article
- A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer.Brain, behavior, & immunity - health · 2022Review
- Functional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer.JCO oncology practice · 2021Article
- Spousal Influences on Monthly Disability in Late-Life Marriage in the Precipitating Events Project.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Longitudinal trajectory of disability in community-dwelling older adults: An observational cohort study in South Korea.BMC geriatrics · 2020Observational
- Severe functional limitation due to pain & emotional distress and subsequent receipt of prescription medications among older adults with cancer.Journal of geriatric oncology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundTo characterize functional trajectories in the year before and after a new cancer diagnosis among older adults and to identify risk factors for worsening disability post-diagnosis.
methodsWe identified 170 participants 70+ years with monthly assessments of thirteen basic, instrumental, and mobility activities and with a new cancer diagnosis from 1998 to 2014. A group-based trajectory model identified distinct functional trajectories based on a total disability score during the twelve months pre- and post-diagnosis. We evaluated associations between potential risk factors at the time of cancer diagnosis and worsening disability post-diagnosis, explored functional transitions from pre- to post-diagnosis and identified participants whose functional trajectories worsened.
resultsThree pre-diagnosis functional trajectories were identified among 170 participants (mean age at diagnosis: 83 years (range: 73-105 years): mild, moderate, and severe disability. Three post-diagnosis functional trajectories were identified among 158 non-decedents: mild, moderate, and severe disability. Most participants (93.9%) with severe disability pre-diagnosis had severe disability post-diagnosis. Risk factors independently associated with worsening disability post-diagnosis included moderate or severe disability pre-diagnosis (adjusted risk ratio, aRR: moderate: 2.96; 95%CI: 2.11-4.16; severe: 5.11; 95%CI: 3.07-8.52) vs. mild (reference), poor physical capability (aRR: 1.57; 95%CI: 1.07-2.30), and incurable stage (aRR:1.99; 95%CI: 1.41-2.80). 40% of participants with a mild or moderate disability trajectory pre-diagnosis transitioned to a worse functional trajectory post-diagnosis.
conclusionOlder adults followed distinct functional trajectories in the twelve months before and after cancer diagnosis. Functional trajectory pre-diagnosis, poor physical capability, and incurable stage were independent risk factors for worsening disability post-diagnosis.
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