ArticleCurrent biology : CB2018
Electrostatic Tuning of a Potassium Channel in Electric Fish.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Electrostatic tuning of NaThe Journal of physiology · 2026Article
- Developmental and evolutionary changes in sensorimotor integration to maintain coordination of corollary discharge and afferent input in electric fish.Current biology : CB · 2026Article
- Gene and allele-specific expression during electric organ ontogeny in African weakly electric fish (Campylomormyrus).Communications biology · 2026Article
- Gene expression correlates and mechanistic insights into electric organ discharge duration changes in mormyrid electric fish.The Journal of experimental biology · 2025Article
- Organization of the stalk system on electrocytes in mormyrid weakly electric fish Campylomormyrus compressirostris.Cell and tissue research · 2025Article
- Dual mechanisms contribute to enhanced voltage dependence of an electric fish potassium channel.Biophysical journal · 2024Article
- Ecologically mediated differences in electric organ discharge drive evolution in a sodium channel gene in South American electric fishes.Biology letters · 2024Article
- Gene and Allele-Specific Expression Underlying the Electric Signal Divergence in African Weakly Electric Fish.Molecular biology and evolution · 2024Article
- A new genome assembly of an African weakly electric fish (Campylomormyrus compressirostris, Mormyridae) indicates rapid gene family evolution in Osteoglossomorpha.BMC genomics · 2023Article
- Molecular evolution of the ependymin-related gene epdl2 in African weakly electric fish.G3 (Bethesda, Md.) · 2023Article
- Advancing human disease research with fish evolutionary mutant models.Trends in genetics : TIG · 2022Review
- Morphological diversity of acoustic and electric communication systems of mochokid catfish.The Journal of comparative neurology · 2021Article
- Comparative Assessment of Familiarity/Novelty Preferences in Rodents.Frontiers in behavioral neuroscience · 2021Article
- Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior.Frontiers in neural circuits · 2021Review
- Dynamics of a neuronal pacemaker in the weakly electric fish Apteronotus.Scientific reports · 2020Article
- Ontogeny of electric organ and electric organ discharge in Campylomormyrus rhynchophorus (Teleostei: Mormyridae).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Studying convergent evolution to relate genotype to behavioral phenotype.The Journal of experimental biology · 2020Review
- The transcriptional correlates of divergent electric organ discharges in Paramormyrops electric fish.BMC evolutionary biology · 2020Article
- Article
- Phenotypic evolution shaped by current enzyme function in the bioluminescent courtship signals of sea fireflies.Proceedings. Biological sciences · 2019Article
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Abstract
Molecular variation contributes to the evolution of adaptive phenotypes, though it is often difficult to understand precisely how. The adaptively significant electric organ discharge behavior of weakly electric fish is the direct result of biophysical membrane properties set by ion channels. Here, we describe a voltage-gated potassium-channel gene in African electric fishes that is under positive selection and highly expressed in the electric organ. The channel produced by this gene shortens electric organ action potentials by activating quickly and at hyperpolarized membrane potentials. The source of these properties is a derived patch of negatively charged amino acids in an extracellular loop near the voltage sensor. We demonstrate that this negative patch acts by contributing to the global surface charge rather than by local interactions with specific amino acids in the channel's extracellular face. We suggest a more widespread role for this loop in the evolutionary tuning of voltage-dependent channels.
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