ArticleCortex; a journal devoted to the study of the nervous system and behavior2019
What is special about the human arcuate fasciculus? Lateralization, projections, and expansion.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 134 citations in OpenAlex.
- Comparing the Limbic-Frontal Connectome across the Primate Order: Conservation of Connections and Implications for Translational Neuroscience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The white matter of Aha! moments.BMC psychology · 2026Article
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- Insights From Language-Trained Apes: Brain Network Plasticity and Communication.Evolutionary anthropology · 2025Review
- Short-range human cortico-cortical white matter fibers have thinner axons and are less myelinated compared to long-range fibers despite a similar g-ratio.PLoS biology · 2025Article
- Long arcuate fascicle in wild and captive chimpanzees as a potential structural precursor of the language network.Nature communications · 2025Article
- The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy.Brain : a journal of neurology · 2025Review
- White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity and category-selectivity from birth.Nature human behaviour · 2025Article
- Enlargement of the human prefrontal cortex and brain mentalizing network: anatomically homogenous cross-species brain transformation.Brain structure & function · 2025Article
- White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity, and category-selectivity from birth.bioRxiv : the preprint server for biology · 2025Article
- Clinical implications of sagittal stratum damage: Laterality, neuroanatomical developmental considerations, and functional outcomes.Surgical neurology international · 2025Review
- Investigating the role of the left inferior frontal gyrus in language evolution: insights from comparative neuroscience.Frontiers in human neuroscience · 2025Review
- A whole-brain structural connectivity signature in adult Niemann-Pick disease type C.Brain communications · 2025Article
- Article
- A map of white matter tracts in a lesser ape, the lar gibbon.Brain structure & function · 2024Article
- Generalising XTRACT tractography protocols across common macaque brain templates.Brain structure & function · 2024Article
- The neocortical infrastructure for language involves region-specific patterns of laminar gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain.Nature communications · 2024Article
- Detailed mapping of the complex fiber structure and white matter pathways of the chimpanzee brain.Nature methods · 2024Article
- Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Evolutionary adaptations of the human brain are the basis for our unique abilities such as language. An expansion of the arcuate fasciculus (AF), the dorsal language tract, in the human lineage involving left lateralization is considered canonical, but this hypothesis has not been tested in relation to other architectural adaptations in the human brain. Using diffusion-weighted MRI, we examined AF in the human and macaque and quantified species differences in white matter architecture and surface representations. To compare surface results in the two species, we transformed macaque representations to human space using a landmark-based monkey-to-human cortical expansion model. We found that the human dorsal AF, but not the ventral inferior fronto-occipital fasciculus (IFO), is left-lateralized. In the monkey AF is not lateralized. Moreover, compared to the macaque, human AF is relatively increased with respect to IFO. A comparison of human and transformed macaque surface representations suggests that cortical expansion alone cannot account for the species differences in the surface representation of AF. Our results show that the human AF has undergone critical anatomical modifications in comparison with the macaque AF. More generally, this work demonstrates that studies on the human brain specializations underlying the language connectome can benefit from current methodological advances in comparative neuroanatomy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.