Evidence map›Paper›PMID 29937164›Full record

ArticleSurgical oncology2018

External validation of a modified 8th AJCC TNM system for advanced gastric cancer: Long-term results in southern China.

Jinning Ye, Yufeng Ren, Zhewei Wei, Xun Hou, Weigang Dai, Shirong Cai, Min Tan, Yulong He, Yujie Yuan

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  13. Multiple metabolic parameters and visual assessment ofAbdominal radiology (New York) · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jinning YeCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: yejn@mail.sysu.edu.cn.
Yufeng RenDepartment of Radiation Oncology, The First Affiliated Hospital, Sun Yat-Sen University, PR China. Electronic address: renyuf@mail.sysu.edu.cn.
Zhewei WeiCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: denisewei@126.com.
Xun HouCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: kris.hou@foxmail.com.
Weigang DaiCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: daiweigang1@163.com.
Shirong CaiCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: caicai_sysu@126.com.
Min TanCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: tantommy@126.com.
Yulong HeCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: yulongh.sysu@gmail.com.
Yujie YuanCenter of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, PR China; Center of Gastric Cancer, Sun Yat-Sen University, PR China. Electronic address: condor.yyj@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 8th edition of AJCC TNM staging manual for gastric cancer (GC) has been validated by several studies. A modified staging system based on it and total harvested number of lymph nodes (LNs; cutoff: 30) is suggested to improve predictive capacities for advanced GC. This study is designed to validate the modified method using a single-center database in Southern China.

methodsClinical data from 684 GC patients with stage II and III according to the 7th edition between 2001 and 2012 were reviewed. A modified staging system was applied to restage the cohort. The three staging systems were compared in terms of prognostic performance on long-term survival.

resultsThe median follow-up period of this cohort was 52 (range, 6-180) months, with a median 5-year overall survival rate of 52.4%. Stage migration was observed in 159 (23.2%) patients according to the 8th edition of TNM staging, and another migration was observed in 108 (15.8%) patients according to the modified TNM staging system. Compared with the modified staging system, both 7th and 8th edition of AJCC TNM staging systems did not prove survival concordance on stage IIIA (7th edition) and stage IIIC (8th edition) when <30 LNs were examined. The survival performance between two AJCC staging systems had no significant improvement (c-index, 0.607 vs. 0.609), with the best prognostic stratification obtained using the modified staging method (c-index, 0.631).

conclusionsThe modified staging system on basis of the 8th AJCC classification and the number of harvested LNs could provide an optimal predictive capacities for advanced gastric cancer.

Indexed as

AdultAgedAged, 80 and overChinaDatabases, FactualFemaleFollow-Up StudiesHumansLymph NodesMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingProspective StudiesRetrospective StudiesStomach Neoplasms8th editionAmerican joint committee on cancerGastric cancer

Identifiers

PMID29937164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.