Evidence map›Paper›PMID 29937143›Full record

ArticleStem cell reports2018

ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and Repopulation of Hematopoietic Stem Cells.

Yu-Feng Liu, Shao-Ying Zhang, Ying-Ying Chen, Kun Shi, Bin Zou, Jun Liu, Qiong Yang, Hua Jiang, Lai Wei, Chang-Zheng Li and 4 more

Abstract read
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
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  5. Article
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  7. Article
  8. Article
  9. Review
  10. Journal of immunology research · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Adaptive responses toProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Review
  18. Article
  19. Stem cell quiescence and its clinical relevance.World journal of stem cells · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu-Feng LiuKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China.
Shao-Ying ZhangNational & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital, Xi'an Jiaotong University, Xian 710000, China; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Ying-Ying ChenInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Kun ShiGuangzhou Women and Children's Medical Center, Guangzhou 510000, China.
Bin ZouZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Jun LiuInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Qiong YangInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Hua JiangGuangzhou Women and Children's Medical Center, Guangzhou 510000, China.
Lai WeiZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Chang-Zheng LiKey Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Guangzhou 510080, China.
Meng ZhaoKey Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Guangzhou 510080, China.
Dmitry I GabrilovichInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Disease Control, Chinese Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China; The Wistar Institute, Philadelphia, PA 19104, USA.
Hui ZhangInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Disease Control, Chinese Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zhangh92@mail.sysu.edu.cn.
Jie ZhouKey Laboratory of Immunology, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Disease Control, Chinese Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zhouj72@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone marrow niche plays a critical role in controlling the fate of hematopoietic stem cells (HSCs) by integrating intrinsic and extrinsic signals. However, the molecular events in the HSC niche remain to be investigated. Here, we report that intercellular adhesion molecule-1 (ICAM-1) maintains HSC quiescence and repopulation capacity in the niche. ICAM-1-deficient mice (ICAM-1

Indexed as

Stem Cell NicheBiomarkersCell CycleCell DifferentiationComputational BiologyGene ExpressionGene Expression ProfilingHematopoietic Stem CellsHumansImmunophenotypingIntercellular Adhesion Molecule-1Neovascularization, PhysiologicVascular DiseasesBiomarkersIntercellular Adhesion Molecule-1bone marrow nichehematopoietic stem cellshomeostasisintercellular adhesion molecule-1

Identifiers

PMID29937143
PMCPMC6117479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.