Evidence map›Paper›PMID 29937115›Full record

Trial reportAmerican journal of preventive medicine2018

Biomedical and Behavioral Outcomes of Keep It Up!: An eHealth HIV Prevention Program RCT.

Brian Mustanski, Jeffrey T Parsons, Patrick S Sullivan, Krystal Madkins, Eli Rosenberg, Gregory Swann

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of preventive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01836445 (Efficacy of Internet-based HIV Prevention), which is not on this map. Cited by 81 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01836445 nacompletednot on this map

Efficacy of Internet-based HIV Prevention

TypeinterventionalSponsorNorthwestern UniversityRan2013 to 2017Enrolled901ConditionsHIV, Gonorrhea, ChlamydiaArmsKeep It Up!, HIV Knowledge Control
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  6. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
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  17. Effectiveness of the smart program: Stepped-care HIV prevention for gay and bisexual adolescent boys.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Trial
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian MustanskiDepartment of Medical Social Sciences, Feinberg School of Medicine and Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Chicago, Illinois. Electronic address: brian@northwestern.edu.
Jeffrey T ParsonsCenter for HIV Educational Studies and Training, Hunter College and the Graduate Center of the City University of New York, New York, New York.
Patrick S SullivanDepartment of Epidemiology and Biostatistics, University at Albany School of Public Health, State University of New York, Rensselaer, New York; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia.
Krystal MadkinsDepartment of Medical Social Sciences, Feinberg School of Medicine and Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Chicago, Illinois.
Eli RosenbergDepartment of Epidemiology and Biostatistics, University at Albany School of Public Health, State University of New York, Rensselaer, New York.
Gregory SwannDepartment of Medical Social Sciences, Feinberg School of Medicine and Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Chicago, Illinois.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Virology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Mohamed Abdel Mohsen · 2015 to 2026
$38.4M
Efficacy of Internet-based HIV preventionR01DA035145 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MUSTANSKI, BRIAN · 2012 to 2016
$3.7M
NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI117943NIDA NIH HHS R01 DA035145
6 · The paper itself

Abstract

introductionHIV diagnoses among young men who have sex with men are increasing, but few effective HIV prevention interventions exist for this population. An RCT was conducted of the online Keep It Up! intervention to determine if it significantly reduced condomless anal sex and sexually transmitted infections compared with an HIV knowledge condition. STUDY

designFrom May 2013 to March 2017, a total of 901 participants were enrolled in a double-blinded RCT of Keep It Up! with 1-year follow-up. After completing baseline surveys and sexually transmitted infection testing, participants were randomized by an eHealth platform to the intervention or control condition. SETTING/

participantsHIV-negative men who have sex with men reporting condomless anal sex, aged 18-29 years, were recruited through advertising and from HIV testing sites and outreach in Atlanta, Georgia; Chicago, Illinois; and New York, New York.

interventionMultimedia was used to address HIV knowledge and motivate safer behaviors. The control condition reflected existing online HIV information.

main outcome measuresPrimary outcomes were incident gonorrhea or chlamydia at 12-month follow-up and self-reported condomless anal sex with casual partners at 3-, 6-, and 12-month follow-up.

resultsIn 2017, data were analyzed from 445 (49%) participants randomized to the intervention and 456 (51%) to the control. Participants were primarily racial/ethnic minorities (63%). Sexually transmitted infections at Month 12 was 40% lower for intervention participants (risk ratio=0.60, 95% CI=0.38, 0.95, p=0.01). For the primary behavioral outcome, both arms showed reductions over time with 44% of control and 37% of intervention participants reporting condomless anal sex at Month 12 (prevalence ratio=0.83, 95% CI=0.70, 0.99, p=0.04).

conclusionsThe Keep It Up! intervention resulted in significantly lower sexually transmitted infection incidence and a small but significant decrease in condomless anal sex 12 months post-intervention relative to an online HIV knowledge condition. In addition, this study demonstrated the feasibility and acceptability of at-home sexually transmitted infection testing as part of an eHealth intervention.

trial registrationThis study is registered at www.clinicaltrials.gov NCT01836445.

Indexed as

Health Knowledge, Attitudes, PracticeAdultHIV InfectionsHomosexuality, MaleHumansMaleRisk Reduction BehaviorSexually Transmitted DiseasesSurveys and QuestionnairesTelemedicineUnited StatesYoung Adult

Identifiers

PMID29937115
PMCPMC6314292

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.