ArticleAmerican journal of human genetics2018
Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection.
Article in American journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- A novel method for across-chromosome phasing without relative data.Bioinformatics (Oxford, England) · 2026Article
- COMPADRE: Combined pedigree-aware distant relatedness estimation for improved pedigree reconstruction.American journal of human genetics · 2025Article
- A likelihood ratio framework for inferring close kinship from dynamically selected SNPs.Frontiers in genetics · 2025Article
- CORRECTING MODEL MISSPECIFICATION IN RELATIONSHIP ESTIMATES.bioRxiv : the preprint server for biology · 2024Article
- Reconstructing parent genomes using siblings and other relatives.bioRxiv : the preprint server for biology · 2024Article
- FiMAP: A fast identity-by-descent mapping test for biobank-scale cohorts.PLoS genetics · 2023Article
- A cost-benefit analysis for use of large SNP panels and high throughput typing for forensic investigative genetic genealogy.International journal of legal medicine · 2023Article
- RaPID-Query for fast identity by descent search and genealogical analysis.Bioinformatics (Oxford, England) · 2023Article
- Evaluating the utility of identity-by-descent segment numbers for relatedness inference via information theory and classification.G3 (Bethesda, Md.) · 2022Article
- A machine learning approach for missing persons cases with high genotyping errors.Frontiers in genetics · 2022Article
- GRAPE: genomic relatedness detection pipeline.F1000Research · 2022Article
- Bonsai: An efficient method for inferring large human pedigrees from genotype data.American journal of human genetics · 2021Article
- Fast and Robust Identity-by-Descent Inference with the Templated Positional Burrows-Wheeler Transform.Molecular biology and evolution · 2021Article
- On the application, reporting, and sharing of in silico simulations for genetic studies.Genetic epidemiology · 2021Review
- Distinguishing pedigree relationships via multi-way identity by descent sharing and sex-specific genetic maps.American journal of human genetics · 2021Article
- RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID.PLoS genetics · 2021Article
- Rapid, Phase-free Detection of Long Identity-by-Descent Segments Enables Effective Relationship Classification.American journal of human genetics · 2020Article
- Article
- Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives.PLoS genetics · 2019Article
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9 authors.
Funding
Abstract
As genetic datasets increase in size, the fraction of samples with one or more close relatives grows rapidly, resulting in sets of mutually related individuals. We present DRUID-deep relatedness utilizing identity by descent-a method that works by inferring the identical-by-descent (IBD) sharing profile of an ungenotyped ancestor of a set of close relatives. Using this IBD profile, DRUID infers relatedness between unobserved ancestors and more distant relatives, thereby combining information from multiple samples to remove one or more generations between the deep relationships to be identified. DRUID constructs sets of close relatives by detecting full siblings and also uses an approach to identify the aunts/uncles of two or more siblings, recovering 92.2% of real aunts/uncles with zero false positives. In real and simulated data, DRUID correctly infers up to 10.5% more relatives than PADRE when using data from two sets of distantly related siblings, and 10.7%-31.3% more relatives given two sets of siblings and their aunts/uncles. DRUID frequently infers relationships either correctly or within one degree of the truth, with PADRE classifying 43.3%-58.3% of tenth degree relatives in this way compared to 79.6%-96.7% using DRUID.
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