Evidence map›Paper›PMID 29937004›Full record

ArticleThe Journal of surgical research2018

Anemia and blood transfusion in elderly trauma patients.

Tyler J Loftus, Scott C Brakenridge, Travis W Murphy, Linda L Nguyen, Frederick A Moore, Philip A Efron, Alicia M Mohr

Abstract read
In one paragraph

Article in The Journal of surgical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Observational
  3. Influence of anaemia in severely injured patients on mortality, transfusion and length of stay: an analysis of the TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Early Outcomes After Surgical Management of Geriatric Patella Fractures.Geriatric orthopaedic surgery & rehabilitation · 2021
    Article
  9. Article
  10. Paradigm shift in geriatric fracture treatment.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tyler J LoftusDepartment of Surgery, University of Florida, Gainesville, Florida; Sepsis and Critical Illness Research Center, Gainesville, Florida.
Scott C BrakenridgeDepartment of Surgery, University of Florida, Gainesville, Florida; Sepsis and Critical Illness Research Center, Gainesville, Florida.
Travis W MurphyDepartment of Surgery, University of Florida, Gainesville, Florida.
Linda L NguyenUniversity of Florida College of Medicine, Gainesville, Florida.
Frederick A MooreDepartment of Surgery, University of Florida, Gainesville, Florida; Sepsis and Critical Illness Research Center, Gainesville, Florida.
Philip A EfronDepartment of Surgery, University of Florida, Gainesville, Florida; Sepsis and Critical Illness Research Center, Gainesville, Florida.
Alicia M MohrDepartment of Surgery, University of Florida, Gainesville, Florida; Sepsis and Critical Illness Research Center, Gainesville, Florida. Electronic address: alicia.mohr@surgery.ufl.edu.
University of Florida · USMental Illness Research, Education and Clinical Centers · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Chronic Stress and Anemia Recovery following Major TraumaR01GM105893 · NIGMS · UNIVERSITY OF FLORIDA · PI MOHR, ALICIA M · 2013 to 2021
$3.5M
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6M
NCATS NIH HHS UL1 TR001427NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM105893NIGMS NIH HHS R01 GM113945NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

backgroundThe natural history of postinjury among elderly trauma patients has not been well described. We hypothesized that elderly trauma patients would have lower admission hemoglobin (Hb) levels, higher transfusion rates, and worse outcomes than young trauma patients.

methodsWe performed a propensity-matched retrospective cohort analysis comparing elderly (age ≥65 y) to young (age 18-64) trauma patients matched by sex, mechanism of injury, Injury Severity Score, base deficit, comorbidities, operative blood loss, and phlebotomy blood loss (n = 41/group). Outcomes included Hb trends, packed red blood cell (PRBC) transfusion, length of stay, and mortality.

resultsElderly patients had lower admission Hb (11.3 versus 10.2 g/dL, P = 0.012), received more PRBC transfusions within 24 h (3.6 versus 1.8 units, P = 0.046), and during admission (6.9 versus 4.3 units, P = 0.008). Despite receiving more PRBC transfusions and having similar operative and phlebotomy blood loss, elderly subjects had lower discharge Hb (9.0 versus 9.7 g/dL, P = 0.013). Elderly subjects had fewer ICU-free days (2.0 versus 6.0 d, P < 0.001) and higher in-hospital mortality (15% versus 0%, P = 0.026).

conclusionsElderly trauma patients had lower admission Hb, received more transfusions, and had persistently lower Hb on discharge when controlling for injury severity, comorbid conditions, and blood loss. Aging may have a negative impact on postinjury anemia.

Indexed as

AdultAgedAged, 80 and overAge FactorsAgingAnemiaBlood Loss, SurgicalErythrocyte TransfusionFemaleHemoglobinsHospital MortalityHumansInjury Severity ScoreIntensive Care UnitsLength of StayMaleHemoglobinsAgingAnemiaGeriatricInjuryTransfusionTrauma

Identifiers

PMID29937004
PMCPMC6029697
OpenAlexW2809384788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.