Evidence map›Paper›PMID 29936925›Full record

ArticleThe British journal of nutrition2018

Maternal vitamin D and neonatal anthropometrics and markers of neonatal glycaemia: Belfast Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study.

Claire Casey, Ann McGinty, Valerie A Holmes, Chris C Patterson, Ian S Young, David R McCance

Abstract readMulticenter Study
In one paragraph

Article in The British journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claire Casey1Centre for Public Health,Queen's University Belfast,Belfast BT12 6BA,Northern Ireland,UK.ORCID 0000-0001-9188-6801
Ann McGinty1Centre for Public Health,Queen's University Belfast,Belfast BT12 6BA,Northern Ireland,UK.
Valerie A Holmes1Centre for Public Health,Queen's University Belfast,Belfast BT12 6BA,Northern Ireland,UK.
Chris C Patterson1Centre for Public Health,Queen's University Belfast,Belfast BT12 6BA,Northern Ireland,UK.
Ian S Young1Centre for Public Health,Queen's University Belfast,Belfast BT12 6BA,Northern Ireland,UK.
David R McCance1Centre for Public Health,Queen's University Belfast,Belfast BT12 6BA,Northern Ireland,UK.

Funding

Hyperglycemia and Adverse Pregnancy Outcome (HAPO)R01HD034243 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI METZGER, BOYD E · 1999 to 2010
$16.2M
HAPO: DATA COORDINATING CENTERR01HD034242 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DYER, ALAN R · 1999 to 2007
$3.0M
NICHD NIH HHS R01 HD034242NICHD NIH HHS R01 HD034243
6 · The paper itself

Abstract

Vitamin D deficiency is a common occurrence globally, and particularly so in pregnancy. There is conflicting evidence regarding the role of vitamin D during pregnancy in non-skeletal health outcomes for both the mother and the neonate. The aim of this study was to investigate the associations of maternal total 25-hydroxy vitamin D (25OHD) with neonatal anthropometrics and markers of neonatal glycaemia in the Belfast centre of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. Serological samples (n 1585) were obtained from pregnant women in the Royal Jubilee Maternity Hospital, Belfast, Northern Ireland, between 24 and 32 weeks' gestation as part of the HAPO study. 25OHD concentrations were measured by liquid chromatography tandem-MS. Cord blood and neonatal anthropometric measurements were obtained within 72 h of birth. Statistical analysis was performed. After adjustment for confounders, birth weight standard deviation scores (SDS) and birth length SDS were significantly associated with maternal total 25OHD. A doubling of maternal 25OHD at 28 weeks' gestation was associated with mean birth weight SDS and mean birth length SDS higher by 0·05 and 0·07, respectively (both, P=0·03). There were no significant associations with maternal 25OHD and other measures of neonatal anthropometrics or markers of neonatal glycaemia. In conclusion, maternal total 25OHD during pregnancy was independently associated with several neonatal anthropometric measurements; however, this association was relatively weak.

Indexed as

AdultAnthropometryBirth WeightBlood GlucoseDiabetes, GestationalDiabetes MellitusFastingFemaleFetal BloodGestational AgeGlucose Tolerance TestHomeostasisHumansHyperglycemiaInfant, NewbornInsulin-Secreting CellsBlood GlucoseVitamin D25OHD 25-hydroxy vitamin D3-epi-25OHD2/D3 3-epi-25hydroxyvitamin D2/D3GlycaemiaGrowth developmentHAPO Hyperglycemia and Adverse Pregnancy OutcomeHOMA-IR homoeostatic model assessment of insulin resistanceHOMA-β homoeostatic model of assessment-βNeonatesOGTT oral glucose tolerance testingPregnancyQC quality controlSDS standard deviation scoreVitamin D

Identifiers

PMID29936925
PMCPMC6023417

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.