Evidence map›Paper›PMID 29936863›Full record

ArticleAIDS research and human retroviruses2018

Early Presence of HIV-1 Subtype C in Washington, D.C.

Zehava Grossman, Sheryl-Vi Rico, Katherine Cone, Wei Shao, Catherine Rehm, Sara Jones, Giorgio Bozzi, Sophie Dean, Robin Dewar, Tauseef Rehman and 4 more

Abstract readCase Reports
In one paragraph

Article in AIDS research and human retroviruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zehava Grossman1 HIV Dynamics and Replication Program, NCI , NIH, Frederick, Maryland.
Sheryl-Vi Rico3 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases , NIH, Bethesda, Maryland.
Katherine Cone3 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases , NIH, Bethesda, Maryland.
Wei Shao5 Leidos Biomedical Research, Inc. , Frederick, National Laboratory for Cancer Research, Frederick, Maryland.
Catherine Rehm3 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases , NIH, Bethesda, Maryland.
Sara Jones6 Clinical Monitoring Research Program, Leidos Biomedical Research, Inc. , NCI Campus at Frederick, Frederick, Maryland.
Giorgio Bozzi1 HIV Dynamics and Replication Program, NCI , NIH, Frederick, Maryland.
Sophie Dean1 HIV Dynamics and Replication Program, NCI , NIH, Frederick, Maryland.
Robin Dewar5 Leidos Biomedical Research, Inc. , Frederick, National Laboratory for Cancer Research, Frederick, Maryland.
Tauseef Rehman5 Leidos Biomedical Research, Inc. , Frederick, National Laboratory for Cancer Research, Frederick, Maryland.
Julia Purdy7 Critical Care Medicine Department, NIH Clinical Center , NIH, Bethesda, Maryland.
Colleen Hadigan3 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases , NIH, Bethesda, Maryland.
Alice K Pau8 Intramural Clinical Management & Operations Branch , NIAID, NIH, Bethesda, Maryland.
Frank Maldarelli1 HIV Dynamics and Replication Program, NCI , NIH, Frederick, Maryland.

Funding

HIV-1 Genetic Variation in Infected IndividualsZIABC010819 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MALDARELLI, FRANK · 2009 to 2025
$9.9M
6 · The paper itself

Abstract

The presence of non-B HIV subtypes in the USA has been documented during the epidemic, although the timing of early introductions of different subtypes remains uncertain. Subtype C, the most common HIV variant worldwide, was first reported in the USA in 1996-97, after subtype C had expanded greatly in sub-Saharan Africa. In this study, we report a patient with subtype C infection acquired by mother-to-child transmission, born in the USA in 1990 to a Washington, D.C. resident who never traveled outside the USA, demonstrating that subtype C was present in the USA much earlier. Comparative analysis of the sequence from this patient and subtype C sequences in the USA and elsewhere suggest multiple independent introductions of this subtype into the USA have taken place, many of which are traced to sub-Saharan or East Africa. These data indicate subtype C HIV was already present in the USA years earlier than previously reported, and during the early period of subtype C expansion.

Indexed as

GenotypeChildDistrict of ColumbiaFemaleHIV-1HIV InfectionsHumansInfant, NewbornInfectious Disease Transmission, VerticalMolecular EpidemiologyPregnancyD.C.HIV-1 subtype CHIV epidemiologytransmission in Washington

Identifiers

PMID29936863
PMCPMC6080110

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