Evidence map›Paper›PMID 29936624›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment.

J Cave, A Paschalis, C Y Huang, M West, E Copson, S Jack, M P W Grocott

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07453173 (A Pilot, Single-Arm, Prospective Study Assessing Feasibility and Safety of a Supervised Progressive Resistance Training Program During Total NeoadjuvantTherapy), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07453173 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot, Single-Arm, Prospective Study Assessing Feasibility and Safety of a Supervised Progressive Resistance Training Program During Total NeoadjuvantTherapy (RAPIDO) Until Surgery in Locally Advanced Rectal Cancer

TypeinterventionalSponsorFundacion Arturo Lopez PerezRan2026 to 2027Enrolled15ConditionsLocally Advanced Rectal CancerArmsStrength training program
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  5. The effect of aerobic exercise on tumour blood delivery: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  6. High-intensity interval training in the prehabilitation of cancer patients-a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J CaveDepartment of Medical Oncology, University Hospital Southampton NHS Foundation Trust, MP 307, Tremona Road, Southampton, SO16 6YD, UK. Judith.cave@uhs.nhs.uk.ORCID http://orcid.org/0000-0002-1497-0310
A PaschalisDepartment of Medical Oncology, University Hospital Southampton NHS Foundation Trust, MP 307, Tremona Road, Southampton, SO16 6YD, UK.
C Y HuangDepartment of Acute Internal Medicine, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
M WestDepartment of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
E CopsonDepartment of Medical Oncology, University Hospital Southampton NHS Foundation Trust, MP 307, Tremona Road, Southampton, SO16 6YD, UK.
S JackDepartment of Critical Care Research, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
M P W GrocottDepartment of Critical Care Research, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Funding

Department of Health PB-PG-0609-18262
6 · The paper itself

Abstract

purposeAerobic exercise improves prognosis and quality of life (QoL) following completion of chemotherapy. However, the safety and efficacy of aerobic exercise during chemotherapy is less certain. A systematic review was performed of randomised trials of adult patients undergoing chemotherapy, comparing an exercise intervention with standard care.

methodFrom 253 abstracts screened, 33 unique trials were appraised in accordance with PRISMA guidance, including 3257 patients. Interventions included walking, jogging or cycling, and 23 were of moderate intensity (50-80% maximum heart rate).

resultsAerobic exercise improved, or at least maintained fitness during chemotherapy. Moderately intense exercise, up to 70-80% of maximum heart rate, was safe. Any reported adverse effects of exercise were mild and self-limiting, but reporting was inconsistent. Adherence was good (median 72%). Exercise improved QoL and physical functioning, with earlier return to work. Two out of four studies reported improved chemotherapy completion rates. Four out of six studies reported reduced chemotherapy toxicity. There was no evidence that exercise reduced myelosuppression or improved response rate or survival.

conclusionsExercise during chemotherapy is safe and should be encouraged because of beneficial effects on QoL and physical functioning. More research is required to determine the impact on chemotherapy completion rates and prognosis.

Indexed as

AdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyExerciseExercise TherapyHumansNeoplasmsQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeWalkingCancerChemotherapyPhysical activity

Identifiers

PMID29936624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.