ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018
Portal hypertension and hypersplenism in extrahepatic portal venous obstruction: Are they related?
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Novel postoperative intrahepatic portal venous system classification for prediction of Rex shunt outcome in children with cavernous transformation of the portal vein.Pediatric radiology · 2026Article
- Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices.Pharmacological reports : PR · 2024Article
- Maternal and neonatal outcomes in extra hepatic portal vein obstruction: Our experience.Journal of family medicine and primary care · 2021Article
- Partial Splenic Artery Embolization for the Management of Symptomatic Hypersplenism in Portal Hypertension: Clinical Insights from a Case Series.Journal of clinical and experimental hepatologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
BACKGROUND AND
aimsPortal hypertension (PHT) due to extrahepatic portal venous obstruction (EHPVO) is common in developing countries. Hypersplenism is a near-constant feature of EHPVO, but its significance, unlike in cirrhotics, is unknown. We aimed to study the relationship between hypersplenism and the severity of PHT in patients with EHPVO.
methodsThis prospective study was done at a tertiary care center from January 2014 to August 2015. All patients with EHPVO who underwent a splenectomy and a shunt or devascularization were included. Data regarding clinical profile, preoperative parameters, and intraoperative details were recorded. The correlation was studied between hypersplenism and the intraoperatively measured portal pressures and markers of PHT.
resultsOf the 40 patients studied (mean [SD] age 22.4 [8.4] years), hematological hypersplenism was present in 39 (97.5%). The mean (SD) hemoglobin, total leukocyte counts (TLC), and platelet counts were 9.9 (2.4) g/dL, 2971 (1239) cells/mm
conclusionsThe platelet counts showed a significant inverse correlation with portal pressures in patients with EHPVO and may be used as surrogate markers of PHT. A platelet count ≤ 53,500 cells/mm
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