Trial reportEuropean journal of pediatrics2018
Epinephrine versus dopamine in neonatal septic shock: a double-blind randomized controlled trial.
Trial report in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06306001 (Intravenous Methylene Blue for Treating Fluid-refractory, Catecholamine-resistant, Neonatal Septic Shock), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intravenous Methylene Blue for Treating Fluid-refractory, Catecholamine-resistant, Neonatal Septic Shock: a Randomized, Placebo-controlled, Superiority Trial
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Neonatal sepsis definitions from randomised clinical trials.Pediatric research · 2023Pooled it
- The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock: a meta-analysis of randomized controlled studies.Italian journal of pediatrics · 2020Pooled it
- Dopamine versus epinephrine for neonatal septic shock: an open labeled, randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- The Inferior Vena Cava Collapsibility Index as a Non-Invasive Haemodynamic Tool in Mechanically Ventilated Surgical Neonates: A Monocentric Observational Study.Children (Basel, Switzerland) · 2026Article
- Article
- Clinical characteristics and short-term outcomes of left ventricular non-compaction cardiomyopathy in neonates.Frontiers in pediatrics · 2026Article
- Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Cardiorespiratory interactions during the transitional period in extremely preterm infants: a narrative review.Pediatric research · 2025Review
- Epinephrine Versus Dopamine in Children, What Is the Current Evidence and What Do We Need? A Systematic Review and Meta-analysis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Analysis of the effects of early screening combined with blood lactate on the severity of patients with sepsis.Heliyon · 2024Article
- An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication.Children (Basel, Switzerland) · 2024Review
- Predicting the effectiveness of drugs used for treating cardiovascular conditions in newborn infants.Pediatric research · 2024Article
- The efficacy and safety of continuous blood purification in neonates with septic shock and acute kidney injury: a two-center retrospective study.European journal of pediatrics · 2024Article
- A pilot randomized controlled trial comparing noradrenaline and adrenaline as a first-line vasopressor for fluid-refractory septic shock in neonates.Frontiers in pediatrics · 2024Article
- Use of vasopressors for septic shock in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Comprehensive Management of Blood Pressure in Patients with Septic AKI.Journal of clinical medicine · 2023Review
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Neonatal septic shock, a focus on first line interventions.Acta bio-medica : Atenei Parmensis · 2022Review
- Hemodynamic dysfunction in neonatal sepsis.Pediatric research · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared epinephrine and dopamine as a first-line vasoactive drug in 40 neonates (enrolled in two gestational age strata ≤ 30
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.