ArticleSkeletal radiology2018
Chemical shift imaging with in-phase and opposed-phase sequences at 3 T: what is the optimal threshold, measurement method, and diagnostic accuracy for characterizing marrow signal abnormalities?
Article in Skeletal radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- How I Do It: MRI of the Bone with Marrow-specific Sequences.Radiology · 2025Review
- In-phase and opposed-phase Dixon chemical shift imaging for the assessment of skeletal marrow lesions: comparison of measurements from longitudinal sequences to those from axial sequences.The British journal of radiology · 2024Article
- Quantitative biomarkers for distinguishing bone metastasis and benign bone marrow lesions using turbo spin echo T1- and T2-weighted Dixon imaging at 3.0 T.European journal of radiology open · 2023Article
- Do contrast-enhanced and advanced MRI sequences improve diagnostic accuracy for indeterminate lipomatous tumors?La Radiologia medica · 2022Article
- Pediatric skeletal diffusion-weighted magnetic resonance imaging, part 2: current and emerging applications.Pediatric radiology · 2021Review
- Role of in-phase and out-of-phase chemical shift MRI in differentiation of non-neoplastic versus neoplastic benign and malignant marrow lesions.The British journal of radiology · 2021Article
- Quantitative magnetic resonance imaging for determining bone marrow fat fraction at 1.5 T and 3.0 T: a technique to noninvasively assess cellularity and potential malignancy of the bone marrow.Pediatric radiology · 2021Article
- Anomalous signal intensity increase on out-of-phase chemical shift imaging: a manifestation of marrow mineralisation?Skeletal radiology · 2020Article
- Pelvic bone tumor resection: what a radiologist needs to know.Skeletal radiology · 2020Review
- The Dixon technique for MRI of the bone marrow.Skeletal radiology · 2019Review
- Society of Skeletal Radiology 2017 annual meeting summary.Skeletal radiology · 2018Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the threshold signal drop on 3-T chemical shift imaging (CSI), with in-phase (IP) and opposed-phase (OP) sequences, for accurately identifying bone marrow replacement with 100% sensitivity, and determine a clinically useful measurement method for deriving such a threshold. MATERIALS AND
methodsFrom a convenience series of 157 MRIs, 36 cases with histologically proven marrow-replacing lesions and 22 sites of red marrow (histologically proven (2) or with minimum 6-month stability) with 3-Tesla CSI were included. Two musculoskeletal radiologists performed two measurement methods (first: multiple algorithmic ROIs at the top, middle, and bottom of lesions (M-ROI); second: an ROI was drawn where there appeared to be the least opposed-phase signal reduction qualitatively/visually (Q-ROI)). Lesional and red marrow signal change (%,[(IP-OP)signal/IP signal]*100) was determined. Statistical analyses included Student's t test, Cohen's kappa, and receiver operator characteristic curve generation.
resultsBy M-ROI, lesion signal change was - 0.508% (confidence interval (CI) = - 5.537:4.521) and 1.348% (CI = - 3.541:6.311) for readers 1 and 2. By Q-ROI, lesion signal change was - 11.03% (CI = - 17.01:- 5.046) and - 5.657% (CI = - 12.36:1.048) for readers 1 and 2. For all M-ROI and Q-ROI measurement strategies, signal change between lesional tissue and red marrow was significantly different (p < 0.0001). QROI produced the best composite sensitivities and specificities with a maximized Youden index of 0.955-1. A threshold signal drop of 25% with Q-ROI produced at least 100%/86% sensitivity/specificity for both readers for identifying marrow replacement.
conclusionsFor 3-T CSI, a single visually targeted measurement using a 25% threshold is accurate for identifying marrow-replacing lesions.
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